Results 31 to 40 of about 79,911 (264)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Nanomaterials, 2021 Targeted tumor therapy can provide the basis for the inhibition of tumor growth. However, a number of toxin-based therapeutics lack efficacy because of insufficient endosomal escape after being internalized by endocytosis.
Ajmal Zarinwall +6 more
doaj +1 more source
Saponin Biosynthesis in Pulses
Plants, 2022 Pulses are a group of leguminous crops that are harvested solely for their dry seeds. As the demand for plant-based proteins grows, pulses are becoming important food crops worldwide. In addition to being a rich source of nutrients, pulses also contain saponins that are traditionally considered anti-nutrients, and impart bitterness and astringency ...
Yu, Bianyun +2 more
openaire +3 more sources
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Jurnal Sain Peternakan Indonesia, 2016 Peternakan ruminansia merupakan sektor yang sangat penting dalam menyediakan sumber protein hewani. Namun seiring perkembangannya mendapat beberapa kendala terkait dengan produksi metan dari ternak ruminansia yang berdampak negatifbagi penurunan ...
N. Hidayah
doaj +1 more source
Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda +12 more
wiley +1 more source
Evaluation of the effectiveness of saponin biosurfactants in enhancing aqueous-plus-micellar phase solubility of naphthalene oily discharge component [PDF]
Acta Periodica TechnologicaThe micellar solubilization of naphthalene by the natural non-ionic surfactant saponin, obtained from Sapindus mukorossi, was assessed based on its micellar properties. The isolation and purification of saponin were conducted using the microwave-assisted
Ziri Fatima Zohra +3 more
doaj +1 more source
Pharmaceutical Biology, 2023 Context Panax ginseng C. A. Meyer (Araliaceae) is a tonic herb used in ancient Asia.Objective This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.Materials and methods Sprague-Dawley rats were divided into control, model ...
Guolei Zhang +7 more
doaj +1 more source
Advanced Science, EarlyView.Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan +12 more
wiley +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source