Results 61 to 70 of about 516,933 (343)

Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

BMC Cancer, 2019
Background Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis.
Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong, Sung Joo Kim   +7 more
doaj   +1 more source

Ewing`S Sarcoma

Journal of Education, Health and Sport, 2017
Budny Agnieszka, Litak Jakub, Kulesza Bartłomiej, Czyżewski Wojciech, Grochowski Cezary. Ewing`s Sarcoma. Journal of Education, Health and Sport. 2017;7(6):265-272. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.804631 http://ojs.ukw.edu.pl/index.php/johs/article/view/4534 The journal has had 7 points in Ministry of Science and ...
Cezary Grochowski, Jakub Litak, Wojciech Czyżewski, Agnieszka Budny, Bartłomiej Kulesza   +4 more
openaire   +4 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation

Cell Death Discovery
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen   +5 more
doaj   +1 more source

The Prognostic Value of Serum Biomarkers in Localized Bone Sarcoma

Translational Oncology, 2016
OBJECTIVE: Certain biomarkers such as the C-reactive protein, serum albumin, and the neutrophils to lymphocyte ratio are of prognostic significance regarding survival in different types of cancers. Data from sarcoma patients are sparse and mainly derived
Ninna Aggerholm-Pedersen, Katja Maretty-Kongstad, Johnny Keller, Steen Baerentzen, Akmal Safwat   +4 more
doaj   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

eLife, 2018
Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an attractive therapeutic opportunity.
Gerard L. Brien, David Remillard, Junwei Shi, Matthew L. Hemming, J. Chabon, K. Wynne, E. Dillon, G. Cagney, Guido van Mierlo, Marijke P. A. Baltissen, M. Vermeulen, J. Qi, S. Fröhling, N. Gray, J. Bradner, C. Vakoc, S. Armstrong   +16 more
semanticscholar   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Non-Islet Cell Tumor Hypoglycemia Secondary to a 20 cm Intra-Abdominal Leiomyoma in a Male Patient: A Case Report and Literature Review

Case Reports in Surgery
Non-islet cell tumor hypoglycemia (NICTH) is a rare clinical entity associated with large mesenchymal tumors. Its pathogenesis is most commonly mediated by tumor overproduction of “big” insulin-like growth factor-2.
Michelle D. Lippincott, James D. McDonald, Marilyn M. Bui, Ricardo J. Gonzalez, Rachel K. Voss   +4 more
doaj   +1 more source

Lower limb function and quality of life after ILP for soft-tissue sarcoma

World Journal of Surgical Oncology, 2017
Background Isolated limb perfusion with TNF-alpha and melphalan (TM-ILP) in combination with complete tumor resection is an effective treatment option for non-resectable soft-tissue sarcoma of the extremities, with limb salvage rates greater than 80 ...
Lars Erik Podleska, Nevda Kaya, Farhad Farzaliyev, Christoph Pöttgen, Sebastian Bauer, Georg Taeger   +5 more
doaj   +1 more source