Results 241 to 250 of about 65,186 (354)

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Sarcomeric mutations in cardiac diseases [PDF]

Pflügers Archiv - European Journal of Physiology, 2019
Samantha P. Harris, Pieter P. de Tombe
openaire   +3 more sources

Analysis of Sarcomere Lenght Oscillation in Cardiac Muscle Fibers by Confocal Fluorescence Microscopy

, 1999
Darryl Y. Sasaki, Hirotaka Fujita, Sugao Ishiwata   +2 more
openalex   +2 more sources

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, EarlyView.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts. [PDF]

Sci Rep
Wang M, Idei H, Wang C, Liang Y, Liu Y, Matsuda Y, Takahashi K, Kamioka H, Naruse K.   +8 more
europepmc   +1 more source

Consequences of Pressure Overload on Sarcomere Protein Mutation-Induced Hypertrophic Cardiomyopathy [PDF]

, 2003
Joachim P. Schmitt, Christopher Semsarian, Michael Arad, Joseph Gannon, Ferhaan Ahmad, C. Elise Duffy, Richard Lee, Christine E. Seidman, J G Seidman   +8 more
openalex   +1 more source

Sarcomere Gene Mutation correction [PDF]

European Heart Journal, 2018
Sanjiv Kaul, Stephen B. Heitner, Shoukhrat Mitalipov   +2 more
openaire   +3 more sources

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Genetic insights into hypertrophic cardiomyopathy: pathogenesis, diagnosis, and therapeutic implications. [PDF]

J Cardiovasc Imaging
Choi EY, Chung H, Lee KA.
europepmc   +1 more source

Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy

, 2000
Mitsuhiro Kamisago, Sapna Sharma, Steven R. DePalma, Scott D. Solomon, Pankaj Sharma, Barbara McDonough, Leslie Smoot, Mary P. Mullen, Paul K. Woolf, E. Douglas Wigle, J G Seidman, John A. Jarcho, Lawrence R. Shapiro, Christine E. Seidman   +13 more
openalex   +1 more source