Results 261 to 270 of about 35,307 (294)
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Atomistic Simulations of Sarcomere Proteins
2023Concerted atomic motions are requisite for sarcomere protein function and may become disrupted in HCM pathologies. Computational approaches such as molecular dynamics simulation can resolve such dynamics with unrivalled spatial and temporal resolution.
Matthew Carter, Childers +1 more
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Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch
American Journal of Physiology-Cell Physiology, 2012When a stretch is imposed to activated muscles, there is a residual force enhancement that persists after the stretch; the force is higher than that produced during an isometric contraction in the corresponding length. The mechanisms behind the force enhancement remain elusive, and there is disagreement if it represents a sarcomeric property, or if it
Dilson E, Rassier, Ivan, Pavlov
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Sarcomeric Genotyping in Hypertrophic Cardiomyopathy
Mayo Clinic Proceedings, 2005To pool results from studies of patients with hypertrophic cardiomyopathy (HCM) to elucidate important phenotypic differences among genotypes.Data published from November 1998 through November 2004 were gathered and compared from unrelated study population genotyping studies from the Mayo Clinic (Rochester, Minn), Harvard Medical School (Boston, Mass),
Sara L, Van Driest +4 more
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Myofilaments: Movers and Rulers of the Sarcomere
Comprehensive Physiology, 2017ABSTRACT Striated cardiac and skeletal muscles play very different roles in the body, but they are similar at the molecular level. In particular, contraction, regardless of the type of muscle, is a precise and complex process involving the integral protein myofilaments and their associated regulatory components ...
Brian Leei, Lin +2 more
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2010
Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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1989
Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
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Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
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Architecture and function in the muscle sarcomere
Current Opinion in Structural Biology, 1997Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions.
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Inherited disorders of sarcomeric proteins
Current Opinion in Neurology, 1999The most important advances in sarcomeric protein diseases continue to be the identification of mutated genes responsible for human diseases. These have recently included those that encode skeletal muscle alpha-actin in autosomal dominant and autosomal recessive nemaline myopathy, nebulin and slow alpha-tropomyosin in autosomal recessive nemaline ...
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The molecular basis for sarcomere organization in vertebrate skeletal muscle
Cell, 2021Zhexin Wang +2 more
exaly
Sarcomere Function and Crossbridge Cycling
1995The power of the heart is dictated by the force development and velocity of shortening (V) of the cardiac sarcomere. Both depend on the amount of Ca++ released by the sarcoplasmic reticulum during the action potential. We have investigated the inter-relationship between force (F) sarcomere length (SL) and V and the intracellular Ca++ concentration ([Ca+
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