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The Cardiac Sarcomere and Cell Cycle
Current Cardiology Reports, 2022 The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely ...
Anthony M. Pettinato +2 more
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Cardiac sarcomere mechanics in health and disease [PDF]
Biophysical Reviews, 2021 The sarcomere is the fundamental structural and functional unit of striated muscle and is directly responsible for most of its mechanical properties. The sarcomere generates active or contractile forces and determines the passive or elastic properties of
Claudia Crocini +2 more
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Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases
International Journal of Molecular Sciences, 2020 Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance ...
John F Dawson
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Mean sarcomere length-force relationship of rat muscle fibre bundles
Journal of Biomechanics, 1995 To study how sarcomere length inhomogeneities and the duration of activation affect sarcomere length-force characteristics of muscle, the mean sarcomere length-force relationship was determined for twitches and at 100 and 300 ms during tetanic activation
Willem J Van Der Laarse +1 more
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Assembly and maintenance of the sarcomere night and day
Cardiovascular Research, 2007 The assembly of sarcomeric proteins into the highly organized structure of the sarcomere is an ordered and complex process involving an array of structural and associated proteins.
Samuel Y Boateng
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Tearin' Up My Heart: Proteolysis in the Cardiac Sarcomere
Journal of Biological Chemistry, 2011 Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain ...
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The Sarcomere and Sarcomerogenesis
2008Striated muscle owes its name to the microscopic appearance, caused by the longitudinal alignment of thousands of highly ordered contractile units, the sarcomeres. The assembly (and disassembly) of these multiprotein complexes (sarcomere assembly or sarcomerogenesis) follows ordered pathways, which are regulated on the transcriptional, translational ...
Ehler, E, Gautel, M
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On the isometric equation of the sarcomere
Basic Research in Cardiology, 1974A model of the sarcomere is described, which is based upon (a) the sliding filament theory ofHuxley, (b) the ultrastructure of the sarcomere, (c) the biochemical mechanisms responsible for mechanical coupling and uncoupling of myosin and actin, (d) the constancy of the volume of the sarcomere and (e) a statistical analysis of random forces acting on ...
P J, Lewi, W K, Schaper, L M, Gijpen
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Dysfunctional sarcomeric relaxation in the heart
Current Opinion in Physiology, 2022Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relaxation and dysfunction.
Walter E, Knight, Kathleen C, Woulfe
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Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms.
Sarah J. Lehman +2 more
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