Results 111 to 120 of about 140,542 (289)
The efficacy and physiological bases of small muscle mass exercise in health and disease
Experimental Physiology, EarlyView.Abstract The conventional approach to aerobic exercise prescription involves large muscle mass exercise and the manipulation of variables such as training intensity, duration and frequency to promote desired adaptations. However, during whole‐body exercise, central limitations (i.e., neural, pulmonary and/or cardiac) constrain exercise tolerance and ...
Callum G. Brownstein
wiley +1 more source
NMR RELAXATION METHODS TO DETECT PROTEIN DYNAMICS: EVALUATION OF ACCURACY, IMPROVEMENT OF THE METHODOLOGY, AND ITS APPLICATION [PDF]
, 2013 Proteins are dynamic molecules whose ability to undergo conformational changes and fluctuations can impact their biological function, such as enzyme catalysis and substrate recognition. Mutations or perturbations that do not significantly change protein
Myint, Wazo
core
Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes
Experimental Physiology, EarlyView.Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou +11 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, might also be involved in FGF23‐mediated AF.
Qiaoting Yu +7 more
wiley +1 more source
PLoS Computational Biology, 2017 Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling. The key structures responsible for controlling calcium dynamics are the cell membrane (comprising the surface sarcolemma and transverse-tubules), the ...
Michael A Colman +4 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat +3 more
wiley +1 more source
Pulmonary Circulation, 2018 Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca 2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13).
Shin Watanabe +10 more
doaj +1 more source
ORIGINS OF OPEN-CHANNEL NOISE IN THE LARGE POTASSIUM CHANNEL OF SARCOPLASMIC-RETICULUM [PDF]
, 1994 R A Levis +5 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source