Results 11 to 20 of about 140,297 (191)

Sarcoplasmic Reticulum [PDF]

open access: yesThe Journal of General Physiology, 1970
Fragmented sarcoplasmic reticulum (FSR) membranes isolated from rabbit skeletal muscle are impermeable to inulin-14C (mol wt 5,000), and dextran-14C (mol wt 15,000–90,000) at pH 7.0–9.0, yielding an excluded space of 4–5 µl/mg microsomal protein. In the same pH range urea and sucrose readily penetrate the FSR membrane. EDTA or EGTA (1 mM) increased the
P F, Duggan, A, Martonosi
openaire   +2 more sources

Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. [PDF]

open access: yesPLoS ONE, 2016
Abnormal cellular Ca2+ handling contributes to both contractile dysfunction and arrhythmias in heart failure. Reduced Ca2+ transient amplitude due to decreased sarcoplasmic reticulum Ca2+ content is a common finding in heart failure models.
Mani Sadredini   +6 more
doaj   +1 more source

Acetazolamide prevents hypoxia‐induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle

open access: yesPulmonary Circulation, 2021
Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a contributing ...
Larissa A. Shimoda   +6 more
doaj   +1 more source

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

open access: yes, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen   +7 more
core   +1 more source

Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. [PDF]

open access: yesPLoS ONE, 2013
Agonist-stimulated smooth muscle Ca2+ waves regulate blood vessel tone and vasomotion. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were stimulated by a combination of inositol 1,4,5-trisphosphate- and Ca2 ...
Mitra Esfandiarei   +5 more
doaj   +1 more source

Aluminum chloride effect on Ca(2+),Mg(2+)-ATPase activity and dynamic parameters of skeletal muscle contraction [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2015
We studied enzymatic activity and measured strain-gauge contraction properties of the frog Rana temporaria m. tibialis anterior muscle fascicles during the action of aluminum chloride solution. It was shown that AlCl3 solutions did not affect the dynamic
D. M. Nozdrenko   +3 more
doaj   +1 more source

Role of sarcoplasmic reticulum phospholipids in calcium ion binding activity

open access: yesJournal of Lipid Research, 1974
The relationship between sarcoplasmic reticulum phospholipid and Ca2+ binding by sarcoplasmic reticulum membraneswas explored. Ca2+ bound in the absence of ATP was defined as “ATP-independent Ca2+ binding,” and the additional amount of Ca2+ bound in the ...
Joel Steinberg   +2 more
doaj   +1 more source

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

open access: yesFrontiers in Cell and Developmental Biology, 2021
Ca2+ plays a pivotal role in mitochondrial energy production, contraction, and apoptosis. Mitochondrial Ca2+-targeted fluorescent probes have demonstrated that mitochondria Ca2+ transients are synchronized with Ca2+ fluxes occurring in the sarcoplasmic ...
Felipe Salazar-Ramírez   +5 more
doaj   +1 more source

The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart. [PDF]

open access: yesPLoS ONE, 2013
This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes.
Elias Fares   +6 more
doaj   +1 more source

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