The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity. [PDF]
PLoS ONE, 2013 Pyruvate is a metabolic fuel that is a potent inotropic agent. Despite its unique inotropic and antioxidant properties, the molecular mechanism of its inotropic mechanism is still largely unknown.
Carlos A A Torres +4 more
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Activity of Ca(2+),Mg(2+)-ATPase of sarcoplasmic reticulum and contraction strength of the frog skeletal muscles under the effect of organophosphorus insecticides [PDF]
The Ukrainian Biochemical Journal, 2015 The results of an experimental study of organophosphorus insecticides, including pirimiphosmethyl, diazinon and chlorpyrifos caused a decline of the contraction properties in m. tibialis anterior fiber bundles of Rana temporaria, as well as sarcoplasmic
D. M. Nozdrenko +2 more
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Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. [PDF]
PLoS ONE, 2016 Abnormal cellular Ca2+ handling contributes to both contractile dysfunction and arrhythmias in heart failure. Reduced Ca2+ transient amplitude due to decreased sarcoplasmic reticulum Ca2+ content is a common finding in heart failure models.
Mani Sadredini +6 more
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Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. [PDF]
PLoS ONE, 2013 Agonist-stimulated smooth muscle Ca2+ waves regulate blood vessel tone and vasomotion. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were stimulated by a combination of inositol 1,4,5-trisphosphate- and Ca2 ...
Mitra Esfandiarei +5 more
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Pulmonary Circulation, 2021 Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a contributing ...
Larissa A. Shimoda +6 more
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Aluminum chloride effect on Ca(2+),Mg(2+)-ATPase activity and dynamic parameters of skeletal muscle contraction [PDF]
The Ukrainian Biochemical Journal, 2015 We studied enzymatic activity and measured strain-gauge contraction properties of the frog Rana temporaria m. tibialis anterior muscle fascicles during the action of aluminum chloride solution. It was shown that AlCl3 solutions did not affect the dynamic
D. M. Nozdrenko +3 more
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Role of sarcoplasmic reticulum phospholipids in calcium ion binding activity
Journal of Lipid Research, 1974 The relationship between sarcoplasmic reticulum phospholipid and Ca2+ binding by sarcoplasmic reticulum membraneswas explored. Ca2+ bound in the absence of ATP was defined as “ATP-independent Ca2+ binding,” and the additional amount of Ca2+ bound in the ...
Joel Steinberg +2 more
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Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia
Frontiers in Cell and Developmental Biology, 2021 Ca2+ plays a pivotal role in mitochondrial energy production, contraction, and apoptosis. Mitochondrial Ca2+-targeted fluorescent probes have demonstrated that mitochondria Ca2+ transients are synchronized with Ca2+ fluxes occurring in the sarcoplasmic ...
Felipe Salazar-Ramírez +5 more
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The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart. [PDF]
PLoS ONE, 2013 This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes.
Elias Fares +6 more
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Journal of Pharmacological Sciences, 2013 Developmental changes in excitation–contraction mechanisms were examined in the ventricular myocardium from fetal, neonatal, and 1-, 2-, and 4-week-old mice.
Shogo Hamaguchi +6 more
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