Results 21 to 30 of about 42,516 (245)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

Scientific Reports, 2017
GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic.
Yanan Liu, Shelley L. Baumgardt, Juan Fang, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, Jeannette Vásquez-Vivar, Zhengyuan Xia, David C. Warltier, Judy R. Kersten, Zhi-Dong Ge   +10 more
doaj   +1 more source

Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca2+ concentration ([Ca2+]m) modulates the oxidative state and cytosolic Ca2+ regulation.
Sathya Velmurugan, Ting Liu, Kuey C. Chen, Florin Despa, Brian O'Rourke, Sanda Despa   +5 more
doaj   +1 more source

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM

Nature Communications, 2021
Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular
Kellie A. Woll, Omid Haji-Ghassemi, Filip Van Petegem   +2 more
doaj   +1 more source

Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes

European Journal of Translational Myology, 2016
Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the
Hongli Hu, Xing Meng
doaj   +1 more source

Excitation-contraction coupling in zebrafish ventricular myocardium is regulated by trans-sarcolemmal Ca2+ influx and sarcoplasmic reticulum Ca2+ release. [PDF]

PLoS ONE, 2015
Zebrafish (Danio rerio) have become a popular model in cardiovascular research mainly due to identification of a large number of mutants with structural defects.
Moritz Haustein, Tobias Hannes, Jan Trieschmann, Rabea Verhaegh, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Roland Adelmann, Markus Khalil   +8 more
doaj   +1 more source

Fifty-Hertz low frequency magnetic field modifies sarcoplasmic reticulum function [PDF]

E3S Web of Conferences, 2020
Among the putative mechanisms, by which extremely low frequency magnetic field (ELF-MF) modify calcium metabolism is that of affecting Ca2+ fluxes across cell membrane or internal Ca2+ stores.
Lu Jing, Liu Renchen, Wang Zhicheng
doaj   +1 more source

Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+) release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes, RyRs are found in clusters of various sizes and shapes, and RyR cluster size may ...
Samuel Galice, Yuanfang Xie, Yi Yang, Daisuke Sato, Donald M. Bers   +4 more
doaj   +1 more source

Intracellular Membrane Contact Sites in Skeletal Muscle Cells

Membranes
Intracellular organelles are common to eukaryotic cells and provide physical support for the assembly of specialized compartments. In skeletal muscle fibers, the largest intracellular organelle is the sarcoplasmic reticulum, a specialized form of the ...
Matteo Serano, Stefano Perni, Enrico Pierantozzi, Annunziatina Laurino, Vincenzo Sorrentino, Daniela Rossi   +5 more
doaj   +1 more source

The Meeting of Micropeptides with Major Ca²⁺ Pumps in Inner Membranes—Consideration of a New Player, SERCA1b

Membranes, 2023
Calcium is a major signalling bivalent cation within the cell. Compartmentalization is essential for regulation of calcium mediated processes. A number of players contribute to intracellular handling of calcium, among them are the sarco/endoplasmic ...
Ernő Zádor
doaj   +1 more source

SERCA2a: a prime target for modulation of cardiac contractility during heart failure [PDF]

BMB Reports, 2013
Heart failure is one of the leading causes of sudden death indeveloped countries. While current therapies are mostly aimedat mitigating associated symptoms, novel therapies targetingthe subcellular mechanisms underlying heart failure areemerging. Failing
Woo Jin Park, Jae Gyun Oh
doaj   +1 more source