Results 21 to 30 of about 140,297 (191)
Journal of Pharmacological Sciences, 2013 Developmental changes in excitation–contraction mechanisms were examined in the ventricular myocardium from fetal, neonatal, and 1-, 2-, and 4-week-old mice.
Shogo Hamaguchi +6 more
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Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles [PDF]
, 2016 We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles.
Treves S +24 more
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Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia +6 more
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Study of calcium sparks in skeletal and smooth muscle cells in normal and pathological conditions [PDF]
, 2016 mTOR signaling influence a wide range of cellular process including protein synthesis (Iadevaia et al., 2012; Ma and Blenis, 2009; Thoreen et al., 2012), lipids synthesis (Lamming and Sabatini, 2013), transcription (Dibble and Manning, 2013; Vazquez ...
López, Rubén
core +1 more source
Scientific Reports, 2017 GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic.
Yanan Liu +10 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca2+ concentration ([Ca2+]m) modulates the oxidative state and cytosolic Ca2+ regulation.
Sathya Velmurugan +5 more
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Proton permeability of sarcoplasmic reticulum vesicles. [PDF]
, 1980 The proton permeability of rabbit skeletal muscle sarcoplasmic reticulum vesicles was investigated by means of membrane potential measurements. Diffusion potentials were generated in sarcoplasmic reticulum vesicles, rat liver microsomes, and sarcoplasmic
Young, R C, Meissner, G
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The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]
, 2009 The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor +3 more
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Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
Nature Communications, 2021 Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular
Kellie A. Woll +2 more
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European Journal of Translational Myology, 2016 Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the
Hongli Hu, Xing Meng
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