Calcium kinetics of sarcoplasmic reticulum and muscle fatigue
Journal of Physical Fitness and Sports Medicine, 2013 Vigorous muscle contraction ultimately results in an inability to produce the desired force, and this is known as muscle fatigue. Commonly, fatigue may persist for prolonged periods of time, in particular, at low activation frequencies.
Masanobu Wada +2 more
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REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
Nature Communications, 2020 The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility ...
Shin-Haw Lee +18 more
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Cells, 2022 Calreticulin is an endoplasmic Ca2+ binding protein and molecular chaperone. As a cardiac embryonic gene, calreticulin is essential for heart development.
Jody Groenendyk +3 more
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The molecular dysregulation of excitation contraction coupling in patients with congenital muscle disorders [PDF]
, 2015 Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughout the muscle membrane activates muscle contraction, by releasing Ca2+ from the Sarcoplasmic Reticulum (SR).
Rokach, Ori
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Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?
, 2020 Excitation-contraction coupling links excitation of the sarcolemmal surface membrane to mechanical contraction. In the heart this link is established via a Ca-induced Ca release process, which, following sarcolemmal depolarisation, prompts Ca release ...
Beard, Nicole A. +11 more
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Mapping the interactions between ATP and the sarcoplasmic reticulum Ca 2 + -ATPase with ATP and ATP analogs studied by Fourier transform infrared spectroscopy [PDF]
, 2004 Die Infrarotspektroskopie in Verbindung mit photoaktivierbaren Substraten wurde zur Untersuchung von Substrat-Protein-Wechselwirkungen eingesetzt. Dabei wurden Konformationsänderungen der Ca2+-ATPase des Sarkoplasmatischen Retikulums bei Bindung des ...
Liu, Man
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Cardiac muscle thin filament structures reveal calcium regulatory mechanism
Nature Communications, 2020 The contraction of cardiac and skeletal muscles is regulated by Ca2+ released from the sarcoplasmic reticulum in muscle cells. Here the authors provide molecular insights into Ca2+ regulation of muscle contraction by determining the cryo-EM structures of
Yurika Yamada +2 more
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A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
Nature Communications, 2017 Mechanosensitive Piezo channels are important for a wide range of mechanotransduction processes. Here the authors show that Piezos interact with sarcoplasmic /endoplasmic-reticulum Ca2+ ATPases (SERCA) and give mechanistic insights into mechanogating and
Tingxin Zhang +4 more
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PLoS ONE, 2016 An autosomal dominant protein aggregate myopathy, characterized by high plasma creatine kinase and calsequestrin-1 (CASQ1) accumulation in skeletal muscle, has been recently associated with a missense mutation in CASQ1 gene.
Maria Cristina D'Adamo +15 more
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31P NMR Studies of Oriented Multilayers Formed from Isolated Sarcoplasmic Reticulum and Reconstituted Sarcoplasmic Reticulum Evidence that “Boundary-Layer” Phospholipid is not Immobilized [PDF]
, 1981 The major protein constituent of the sarcoplasmic reticulum is the calcium-pump protein which has been dissociated from the sarcoplasmic reticulum membrane and reconstituted to form functional membrane vesicles.
Wang, C.T. +11 more
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