Results 211 to 220 of about 140,542 (289)

Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou, Mingzong Yang, Yang Hu, Xuyun Liu, Han Li, Zihang Feng, Yuxin Xi, Changyang Xing, Lijun Yuan, Jia Li, Shengpeng Wang, Feng Gao, Xing Zhang   +12 more
wiley   +1 more source

The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice. [PDF]

Int J Mol Sci
Kanazawa Y, Takahashi T, Nagano M, Koinuma S, Shigeyoshi Y.   +4 more
europepmc   +1 more source

Sparks of life: Enabling multi‐scale investigations of pro‐arrhythmic calcium‐handling abnormalities

The Journal of Physiology, EarlyView.
Melania Buonocunto, Jordi Heijman
wiley   +1 more source

Do Stimulants Promote Arrhythmic Risk: Insights From a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocyte Model

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
At clinically relevant plasma concentrations, stimulant medications produced minimal effects on conduction velocity but modulated automaticity and repolarization in a hiPSC‐derived cardiomyocyte (hiPSC‐CM) model. These findings provide a foundation for future investigations of stimulant‐associated cardiac safety and support the utility of hiPSC‐CM ...
Alia Arslanova, Samantha Wong, Sonia Franciosi, Glen F. Tibbits, Maksymilian Prondzynski, Shubhayan Sanatani   +5 more
wiley   +1 more source

A simulation study on the role of mitochondria-sarcoplasmic reticulum Ca²⁺ interaction in cardiomyocyte energetics during exercise. [PDF]

J Physiol
Takeuchi A, Matsuoka S.
europepmc   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Transcriptional changes of genes encoding sarcoplasmic reticulum calcium binding and up-taking proteins in normal and Duchenne muscular dystrophy dogs. [PDF]

BMC Musculoskelet Disord
Morales ED, Wang D, Burke MJ, Han J, Devine DD, Zhang K, Duan D.   +6 more
europepmc   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Effects of 8 Weeks of Moderate- or High-Volume Strength Training on Sarcoplasmic Reticulum Ca²⁺ Handling in Elite Female and Male Rowers. [PDF]

Scand J Med Sci Sports
Mazza O, Nielsen J, Mathiesen J, Højme D, Lundby C, Hostrup M, Thomassen M, Plomgaard P, Gejl KD, Ørtenblad N.   +9 more
europepmc   +1 more source

Innovative Dose–Response Assessment of the Metaboreflex With Indirect Control of Intramuscular Metabolic Perturbation in Humans

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim We aimed to evaluate an innovative dose–response approach to assess the metaboreflex with control of intramuscular metabolic perturbation (concept of metaboreflex gain). We also investigated potential sex differences in the metaboreflex using this new approach.
Nabil Kouzkouz, Joris Mallard, Elyse Hucteau, Roland Schott, Xavier Pivot, Guillaume P. Ducrocq, Thomas J. Hureau   +6 more
wiley   +1 more source