Results 201 to 210 of about 140,542 (289)

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1004-1015, October 2026.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the <i>Drosophila</i> Muscle. [PDF]

Biomolecules
Couto-Lima CA, Machado MCR, Anhezini L, Oliveira MT, Molina RADS, da Silva RR, Lopes GS, Trinca V, Colón DF, Peixoto PM, Monesi N, Alberici LC, Ramos RGP, Espreafico EM.   +13 more
europepmc   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Quantification of Sarcoplasmic Reticulum Ca²⁺ Release in Primary Ventricular Cardiomyocytes. [PDF]

Curr Protoc
Afsar MNA, Akter M, Ko CY, Sequeira V, Sequeira V, Olgar Y, Johnson CN.   +6 more
europepmc   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Blink nadir measurements of sarcoplasmic reticulum are consistent with strong local Ca²⁺ depletion. [PDF]

Biophys J
Gillespie D.
europepmc   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2‐Related Centronuclear Myopathy Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Durieux Anne‐Cécile, Arnould David, Velarde Mathias, Allibert Valentine, Paret Chloé, Debelley Quentin, Kizilkilic Esra, Chambon Sidney, Girard Emmanuelle, Collin Louise, Gensel Alexandre, Castells Josiane, Pasternack Aja, Bowen Maximilien, Morel Baptiste, Hourdé Christophe, Laurent Schaeffer, Ritvos Olli, Bitoun Marc, Mounier Rémi, Freyssenet Damien   +20 more
wiley   +1 more source

Myofiber structure, sarcoplasmic reticulum Ca²⁺ handling, and contractile function after muscle-damaging exercise in humans. [PDF]

Physiol Rep
Handegard V, Lunde PK, Frisk M, Seynnes O, Ørtenblad N, Louch WE, Paulsen G, Raastad T.   +7 more
europepmc   +1 more source

Skeletal Muscle Fibre Type Determines Mitochondrial and Metabolic Responses to Hypoxia and Pulmonary Inflammation in Young Adult Rats

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) patients often experience skeletal muscle dysfunction that may result from a complex combination of mitochondrial dysfunction, metabolic reprogramming and fibre type transitions. Among other factors, pulmonary inflammation and hypoxia contribute to the COPD‐associated muscle defects ...
Angelos Gavrielatos, Cécile Cottet‐Rousselle, Noé Brocker, Cindy Tellier, Amel Achouri, Alexandre Prola, Hervé Dubouchaud, Clovis Chabert   +7 more
wiley   +1 more source

Spaceflight increases sarcoplasmic reticulum Ca²⁺ leak and this cannot be counteracted with BuOE treatment. [PDF]

NPJ Microgravity
Braun JL, Fajardo VA.
europepmc   +1 more source