Results 201 to 210 of about 42,516 (245)
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Ca2+ and the sarcoplasmic reticulum
Journal of Molecular and Cellular Cardiology, 1984The role of the sarcoplasmic reticulum in the regulation of cytosolic calcium is briefly reviewed. A method is described for monitoring calcium efflux from relatively large amounts of SR in a newly designed filtration apparatus using membrane filtration.
W G, Nayler, P E, Dresel
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Sarcoplasmic reticulum V. The structure of sarcoplasmic reticulum membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1968Electron microscope analysis of skeletal muscle microsomes was carried out by negative staining with potassium phosphotungstate. The size and shape of microsomes are influenced by species differences, the conditions of preparation and storage. The outer surface of the microsomal membrane is covered by subunits of 40 A diameter, with center to center ...
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Studies of solubilized sarcoplasmic reticulum
Biochemical and Biophysical Research Communications, 1970Abstract The non-ionic detergent Triton X-100 solubilizes most of the protein and phospholipid from the sarcoplasmic reticulum of rabbit skeletal muscle. The calcium dependent ATPase of the sarcoplasmic reticulum is found in the soluble fraction whereas the basic ATPase activity remains insoluble in Triton X-100.
B H, McFarland, G, Inesi
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The Interaction of Drugs with the Sarcoplasmic Reticulum
Annual Review of Pharmacology and Toxicology, 1982Efforts to determine the mechanisms by which drugs interact with membranes can be facilitated by studies of the SR, which has a relatively simple structure. The fact that the SR lacks most of the specific receptors found on other membranes, notably the sarcolemma, is an advantage, as well as a limitation, in that "nonspecific" drug effects can be ...
L, Herbette, F C, Messineo, A M, Katz
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Sarcoplasmic reticulum. IX. The permeability of sarcoplasmic reticulum membranes.
The Journal of general physiology, 1970Fragmented sarcoplasmic reticulum (FSR) membranes isolated from rabbit skeletal muscle are impermeable to inulin-(14)C (mol wt 5,000), and dextran-(14)C (mol wt 15,000-90,000) at pH 7.0-9.0, yielding an excluded space of 4-5 microl/mg microsomal protein. In the same pH range urea and sucrose readily penetrate the FSR membrane.
P F, Duggan, A, Martonosi
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Fractionation of solubilized sarcoplasmic reticulum?
Biochemical and Biophysical Research Communications, 1971Summary A method has been developed which permits the separation of three protein components of the fragmented sarcoplasmic reticular membrane following solubilization with Triton X-100. One fraction contains a 100,000 dalton component and constitutes about 20–30% of the total membrane protein; in this fraction the level of ATPase activity and ...
N, Ikemoto, G M, Bhatnager, J, Gergely
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Endoplasmic and sarcoplasmic reticulum in the heart
Trends in Cell Biology, 2009The concept of the presence of sarcoplasmic reticulum (SR) membrane in the heart is widely accepted and has been considered merely to be a different name for the endoplasmic reticulum (ER) in muscle tissues. Cardiac SR membranes are specialized in the regulation of Ca(2+) transport and control of excitation-contraction coupling.
Marek, Michalak, Michal, Opas
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Phosphorylation of the Sarcoplasmic Reticulum and Sarcolemma
Annual Review of Physiology, 1982The ,a-adrenergic actions of catecholamines represent a key control mecha nism that regulates the metabolic, electrical, and mechanical performance of the myocardium. Cyclic AMP( cAMP) serves as the intracellular second messenger for these regulatory processes in that ,a-adrenergic activation of a sarcolemmal adenylate cyclase causes intracellular ...
M, Tada, A M, Katz
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ATP synthesis in sarcoplasmic reticulum
Archives of Biochemistry and Biophysics, 1972Abstract Previous studies have reported that ATP is synthesized from ADP and P i in systems containing calcium phosphate-loaded sarcoplasmic reticulum membranes. We have repeated and confirmed this work in preparations from lobster tail muscle in which the only energy source was a calcium concentration gradient.
D W, Deamer, R J, Baskin
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The sarcoplasmic reticulum: A comparative study
Comparative Biochemistry and Physiology Part A: Physiology, 1985The diversity of cellular membrane structures associated with regulation of intracellular calcium level is described in several different groups of organisms and cells. All the instances reported refer to cellular processes related to movement, in which calcium ion acts as trigger and/or modulator.
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