Results 181 to 190 of about 42,516 (245)

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

A simulation study on the role of mitochondria-sarcoplasmic reticulum Ca²⁺ interaction in cardiomyocyte energetics during exercise. [PDF]

J Physiol
Takeuchi A, Matsuoka S.
europepmc   +1 more source

Effects of 8 Weeks of Moderate- or High-Volume Strength Training on Sarcoplasmic Reticulum Ca²⁺ Handling in Elite Female and Male Rowers. [PDF]

Scand J Med Sci Sports
Mazza O, Nielsen J, Mathiesen J, Højme D, Lundby C, Hostrup M, Thomassen M, Plomgaard P, Gejl KD, Ørtenblad N.   +9 more
europepmc   +1 more source

THE SARCOPLASMIC RETICULUM OF STRIPED MUSCLE [PDF]

The Journal of Cell Biology, 1956
openaire   +2 more sources

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2151-2156, September 2026.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Ultrastructure of the Epithelium of the Vaginal Complex During the Proestrus and Luteal Phases of the Estrous Cycle in the White‐Eared Opossum (Didelphis albiventris)

Anatomia, Histologia, Embryologia, Volume 55, Issue 5, September 2026.
ABSTRACT The white‐eared opossum (Didelphis albiventris) is a Neotropical opportunistic marsupial widely distributed in the Brazilian territory, occupying both open and forest formations. The anatomy of the marsupial female genital tract consists of two ovaries, oviducts, double uterus, two lateral vaginae, vaginal sinus and a urogenital sinus. The two
Bruno Cesar Schimming, Tais Harumi de Castro Sasahara, Selma Maria Michelin Matheus   +2 more
wiley   +1 more source

Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. [PDF]

ESC Heart Fail
Dewenter M, Seitz T, Steinbrecher JH, Westenbrink BD, Ling H, Lehnart SE, Wehrens XHT, Backs J, Brown JH, Maier LS, Neef S.   +10 more
europepmc   +1 more source

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Protein carbonylation causes sarcoplasmic reticulum Ca²⁺ overload by increasing intracellular Na⁺ level in ventricular myocytes. [PDF]

Pflugers Arch
Bovo E, Seflova J, Robia SL, Zima AV.
europepmc   +1 more source