Results 161 to 170 of about 42,516 (245)

Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage. [PDF]

J Mol Cell Biol
Li A, Shen Y, Li Z, Li L.
europepmc   +1 more source

Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk. [PDF]

JACC Clin Electrophysiol, 2021
Jiang N, Zhou A, Imran H, Shi G, Kaseer B, Siu V, Chu AF, Donaldson DM, Kirk MM, Philips BB, Dudley SC.   +10 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Intercellular NETwork-facilitated sarcoplasmic reticulum targeting for myocardial ischemia-reperfusion injury treatment. [PDF]

Sci Adv
Jiang P, Huang F, Chen L, Zhou H, Deng Y, Li L, Chen M, Huang Y.   +7 more
europepmc   +1 more source

Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia. [PDF]

J Mol Cell Cardiol, 2021
Hamilton S, Terentyeva R, Clements RT, Belevych AE, Terentyev D.   +4 more
europepmc   +1 more source

Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids

The Journal of Physiology, EarlyView.
Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Giulia d'Amati, Silvana Pinelli, Minh Long Hoang, Francesco Paolo Lo Muzio, Michele Miragoli   +7 more
wiley   +1 more source

EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the <i>Drosophila</i> Muscle. [PDF]

Biomolecules
Couto-Lima CA, Machado MCR, Anhezini L, Oliveira MT, Molina RADS, da Silva RR, Lopes GS, Trinca V, Colón DF, Peixoto PM, Monesi N, Alberici LC, Ramos RGP, Espreafico EM.   +13 more
europepmc   +1 more source

Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes. [PDF]

Basic Res Cardiol, 2021
Bogdanov V, Soltisz AM, Moise N, Sakuta G, Orengo BH, Janssen PML, Weinberg SH, Davis JP, Veeraraghavan R, Györke S.   +9 more
europepmc   +1 more source

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman, Yohannes Shiferaw, David Conesa   +2 more
wiley   +1 more source

Blink nadir measurements of sarcoplasmic reticulum are consistent with strong local Ca²⁺ depletion. [PDF]

Biophys J
Gillespie D.
europepmc   +1 more source