Results 151 to 160 of about 140,542 (289)

Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2. [PDF]

Circ Res, 2022
Wleklinski MJ, Kryshtal DO, Kim K, Parikh SS, Blackwell DJ, Marty I, Iyer VR, Knollmann BC.   +7 more
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca²⁺-ATPase (SERCA). [PDF]

Front Immunol, 2022
Selnø ATH, Sumbayev VV, Gibbs BF.
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Sarcoplasmic Reticulum Ca²⁺ Buffer Proteins: A Focus on the Yet-To-Be-Explored Role of Sarcalumenin in Skeletal Muscle Health and Disease. [PDF]

Cells, 2023
Conte E, Dinoi G, Imbrici P, De Luca A, Liantonio A.   +4 more
europepmc   +1 more source

Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids

The Journal of Physiology, EarlyView.
Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Giulia d'Amati, Silvana Pinelli, Minh Long Hoang, Francesco Paolo Lo Muzio, Michele Miragoli   +7 more
wiley   +1 more source

Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass. [PDF]

J Physiol Biochem
Casuso RA.
europepmc   +1 more source

Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure. [PDF]

Proc Natl Acad Sci U S A, 2022
Ren L, Gopireddy RR, Perkins G, Zhang H, Timofeyev V, Lyu Y, Diloretto DA, Trinh P, Sirish P, Overton JL, Xu W, Grainger N, Grainger N, Xiang YK, Dedkova EN, Zhang XD, Yamoah EN, Navedo MF, Thai PN, Chiamvimonvat N.   +19 more
europepmc   +1 more source

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman, Yohannes Shiferaw, David Conesa   +2 more
wiley   +1 more source

The interaction between sarcoplasmic reticulum and mitochondria: a novel mechanism for cardiac arrhythmia. [PDF]

Front Physiol
Yu Z, Zhao M, Xu H, Sun J, Jin X.
europepmc   +1 more source