Results 151 to 160 of about 42,516 (245)

PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca²⁺ Leak in Smooth Muscle Cells. [PDF]

Front Physiol, 2022
Dagnino-Acosta A, Guerrero-Hernandez A.
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum. [PDF]

J Biol Chem
Park T, Forbush K, Li Y, Vivas O, Rosenthal KJ, Falcone J, Wong CJ, Bruce JE, Moreno C, Dessauer CW, Scott JD.   +10 more
europepmc   +1 more source

Disruption of Sarcoplasmic Reticulum-Mitochondrial Contacts Underlies Contractile Dysfunction in Experimental and Human Atrial Fibrillation: A Key Role of Mitofusin 2. [PDF]

J Am Heart Assoc, 2022
Li J, Qi X, Ramos KS, Lanters E, Keijer J, de Groot N, Brundel B, Zhang D.   +7 more
europepmc   +1 more source

A NEW CONFIGURATION OF THE SARCOPLASMIC RETICULUM [PDF]

The Journal of Cell Biology, 1964
openaire   +2 more sources

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

Assaying sarcoplasmic reticulum Ca²⁺-leak in mouse atrial myocytes. [PDF]

Biophys Rep
Xu F, Li JJ, Yang E, Zhang Y, Xie W.
europepmc   +1 more source

Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice. [PDF]

NPJ Microgravity, 2022
Khan AA, Gul MT, Karim A, Ranade A, Azeem M, Ibrahim Z, Ramachandran G, Nair VA, Ahmad F, Elmoselhi A, Qaisar R.   +10 more
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source