Results 211 to 220 of about 2,427 (237)
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THE ENZYMATIC HYDROLYSIS PRODUCTS OF SARIN
Canadian Journal of Biochemistry and Physiology, 1956The hydrolysis of the powerful cholinesterase inhibitor, sarin, by a rat serum enzyme leads almost exclusively to isopropyl methylphosphonic acid, neither methylphosphonic acid nor hydrogen methylphosphonofluoridate being formed. When isopropyl methylphosphonic acid is administered to the intact rat, it is excreted unchanged in the urine.
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Sarin-induced neuropathology in rats
Human & Experimental Toxicology, 1995Sarin, a highly toxic cholinesterase (ChE) inhibitor, administered at near 1 LD50 dose causes severe signs of toxic cholinergic hyperactivity in both the peripheral and central nervous systems (CNS). The present study evaluated acute and long-term neuropathology following exposure to a single LD50 dose of sarin and compared it to lesions caused by ...
Shlomo Shapira +5 more
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Southern Medical Journal, 2013
Given the current geopolitical tensions, the risk of a terrorist attack on the United States is constant and increasing. Chemical terrorism, specifically the use of nerve agents, has occurred in other nations. Because of the ease of manufacture, the ability to conceal them, and the lethality of these agents, they pose a potential threat as a weapon of ...
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Given the current geopolitical tensions, the risk of a terrorist attack on the United States is constant and increasing. Chemical terrorism, specifically the use of nerve agents, has occurred in other nations. Because of the ease of manufacture, the ability to conceal them, and the lethality of these agents, they pose a potential threat as a weapon of ...
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Toxogonin in Sarin, Soman and Tabun poisoning
Biochemical Pharmacology, 1965The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
Birgitta Tolagen, Edith Heilbronn
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Cardiomyopathy in Soman and Sarin intoxicated rats
Toxicology Letters, 1987Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication ...
A.W. Singer +3 more
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Rotational spectrum of cyclohexyl sarin
Journal of Molecular Spectroscopy, 2005Abstract The rotational spectrum of cyclohexyl sarin (also known as GF) has been measured in a jet-cooled expansion using Fourier transform microwave spectroscopy. Two spectra have been observed, each having splittings associated with the internal rotation of the CH3 P group.
Ryan S. DaBell +6 more
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The binding of sarin in the blood plasma of the rat
Biochemical Pharmacology, 1970Abstract Sephadex filtration of serum from rats 10 min after injection of 50 μg/kg of 32 P-sarin demonstrated that about 70 per cent of the radioactivity present in the serum was attached to molecules with a molecular weight above 10,000. Incubation of samples of this serum with oximes caused a decrease in the amounts of 32 P attached to the large ...
Polak, R.L., Cohen, E.M.
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DEVELOPMENTAL TOXICITY OF SARIN IN RATS AND RABBITS
Journal of Toxicology and Environmental Health, 1996Sarin (Agent GB, isopropyl methylphosphonofluoridate) is an organophosphate cholinesterase inhibitor. Sarin (Type I or Type II) was administered by gavage to CD rats on d 6-15 of gestation at dose levels of 0, 100, 240, or 380 micrograms/kg/d and to New Zealand White (NZW) rabbits on d 6-19 of gestation at dose levels of 0, 5, 10, or 15 micrograms/kg/d.
John F. Young +3 more
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STUDIES ON THE ENZYMATIC HYDROLYSIS OF SARIN AND TABUN
Canadian Journal of Biochemistry and Physiology, 1958The enzymes which hydrolyze isopropyl methylphosphonofluoridate (sarin) and ethyl N, N-dimethylphosphoramidocyanidate (tabun) have been studied. Michaelis–Menten constants and activation energies have been estimated and enzyme stability has been studied. The distribution of the enzymes in mammalian tissues has been examined.
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