Results 301 to 310 of about 66,220 (350)
Some of the next articles are maybe not open access.
Urinary metabolites of sarin in a patient of the Matsumoto sarin incident
Archives of Toxicology, 1998Sarin metabolites were measured in urine from a patient with sarin poisoning. Two metabolites, methylphosphonic acid (MPA) and isopropylmethylphosphonic acid (iPMPA), were detected by gas chromatography after conversion to volatile derivatives with N-methyl-N-(tert-butyldimethylsilyl)-trifluoroacetamide in the urine from the victim collected on the ...
T, Nakajima +6 more
openaire +2 more sources
Refractoriness (Tachyphylaxis) to ‘Sarin’
Nature, 1962APART from experiments reported in 1954 by Barnes and Duff1, the occurrence of tachyphylaxis to poisons which act by inhibiting cholinesterase has been little publicized, although the phenomenon appears to offer possibilities as a means of investigating cholinergic function. The following is an account of a method which, in a proportion of experiments,
openaire +2 more sources
Sarin intoxication elevates plasma pralidoxime
Toxicology Letters, 1985Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication.
M D, Green, D E, Jones, D E, Hilmas
openaire +2 more sources
Sarin-induced neuropathology in rats
Human & Experimental Toxicology, 1995Sarin, a highly toxic cholinesterase (ChE) inhibitor, administered at near 1 LD50 dose causes severe signs of toxic cholinergic hyperactivity in both the peripheral and central nervous systems (CNS). The present study evaluated acute and long-term neuropathology following exposure to a single LD50 dose of sarin and compared it to lesions caused by ...
T, Kadar +5 more
openaire +2 more sources
Journal of Chromatography B: Biomedical Sciences and Applications, 1997
A sarin-like organophosphorus agent, [bis(isopropyl methyl)phosphonate; BIMP], was synthesized. This agent has the same phosphonate group as sarin and also has the same anti-acetylcholinesterase activity potency as sarin. The ID50 and LD50 values of BIMP in mice after intravenous injection were 3.9 nM and 0.8 mg/kg, respectively. The AChE activities of
M, Nagao +7 more
openaire +2 more sources
A sarin-like organophosphorus agent, [bis(isopropyl methyl)phosphonate; BIMP], was synthesized. This agent has the same phosphonate group as sarin and also has the same anti-acetylcholinesterase activity potency as sarin. The ID50 and LD50 values of BIMP in mice after intravenous injection were 3.9 nM and 0.8 mg/kg, respectively. The AChE activities of
M, Nagao +7 more
openaire +2 more sources
Sarin Degradation Using Brucite
The Journal of Physical Chemistry C, 2011Density Functional Theory (DFT) calculations with periodic boundary conditions were used to investigate a degradation reaction mechanism of the Sarin molecule (isopropyl methylphosphonofluoridate, C4H10FO2P) using the layered hydroxide brucite (Mg(OH)2).
Viviane S. Vaiss +2 more
openaire +1 more source
Distal sensory axonopathy after sarin intoxication
Neurology, 1998A 51-year-old man inhaled sarin during a terrorist attack on the Tokyo subway system and died 15 months later. Neuropathologic examination revealed marked nerve fiber decrease in the sural nerve, moderate nerve fiber loss in the sciatic nerve, and unremarkable dorsal root ganglia, dorsal roots, and posterior column of the spinal cord. This pathology is
K, Himuro +7 more
openaire +2 more sources
Accidental exposure to sarin: vision effects
Archives of Toxicology, 1985Two men were accidentally exposed to vapors of sarin, a cholinesterase inhibitor and extremely toxic nerve gas. Diagnosis was confirmed by depressed cholinesterase activity, and fixed extremely miotic pupils. No other signs or symptoms developed and neither man required treatment.
openaire +2 more sources