Results 1 to 10 of about 4,209 (128)

SARM regulates cell apoptosis and inflammation during Toxoplasma gondii infection through a multistep mechanism [PDF]

Parasites and Vectors
The sterile alpha and HEAT/Armadillo motif (SARM) is the fifth Toll-like receptor (TLR) adaptor protein containing the Toll/interleukin-1 receptor (TIR) domain, which is highly enriched in the brain. Toxoplasma gondii (T.
Huaiyu Zhou
exaly   +3 more sources

Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305. [PDF]

Rapid Commun Mass Spectrom
2‐Chloro‐4‐[[(1R,2R)‐2‐hydroxy‐2‐methyl‐cyclopentyl]amino]‐3‐methyl‐benzonitrile (LY305) is a transdermal selective androgen receptor modulator (SARM) that has been under development as a potential therapeutic for conditions involving muscle wasting ...
Kobidze G, Möller T, Wen HC, Busardò FP, Thevis M.   +4 more
europepmc   +2 more sources

Social Media, Body Image and Resistance Training: Creating the Perfect ‘Me’ with Dietary Supplements, Anabolic Steroids and SARM’s

Sports Medicine - Open, 2021
Background Few studies have assessed the use of dietary supplements, anabolic androgenic steroids (AAS) and selective androgen receptor modulators (SARM) in male gym users.
Luuk Hilkens, Maarten Cruyff, Catharine Evers   +2 more
exaly   +2 more sources

Spontaneous Acute Left-Sided Abdominal Pain in a Patient With AL Amyloidosis. [PDF]

EJHaem
eJHaem, Volume 7, Issue 4, August 2026.
Malik SAR, Goel U, Valent J, Anwer F.
europepmc   +2 more sources

Expression of sterile-α and armadillo motif containing protein (SARM) in rheumatoid arthritis monocytes correlates with TLR2-induced IL-1β and disease activity

Rheumatology, 2021
Objective Cartilage and bone damage in RA are associated with elevated IL-1β. The effects of IL-1β can be reduced by biological therapies that target IL-1β or TNF-α.
Sarah Unterberger, Neil A. Harrison, Sandra M Sacre   +2 more
exaly   +2 more sources

Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Metabolites, 2021
Selective Androgen Receptor Modulators (SARMs) have anabolic properties but less adverse effects than anabolic androgenic steroids. They are prohibited in both equine and human sports and there have been several cases of SARMs findings reported over the ...
Mikael Hedeland, Mario Thevis, Heather Knych   +2 more
exaly   +2 more sources

SARM suppresses TRIF, TRAF3, and IRF3/7 mediated antiviral signaling in large yellow croaker Larimichthys crocea

Frontiers in Immunology, 2023
As a TIR domain-containing molecular, sterile α-and armadillo motif-containing protein (SARM) acts as an adaptor in Toll-like receptor (TLR) signaling, and also plays important roles in mediating apoptosis and neuronal injury.
J. Zhang, Ying Li, Jun-Chun Tang, K. Li, Juan Shen, Chang Liu, Yong Jiang, Zi Ping Zhang, Yi Wang, P. Zou   +9 more
semanticscholar   +1 more source

The Subcortical Atlas of the Rhesus Macaque (SARM) for neuroimaging

NeuroImage, 2021
Digitized neuroanatomical atlases that can be overlaid onto functional data are crucial for localizing brain structures and analyzing functional networks identified by neuroimaging techniques.
R. Hartig, D. Glen, Benjamin Jung, N. Logothetis, G. Paxinos, E. Garza-Villarreal, A. Messinger, H. Evrard   +7 more
semanticscholar   +1 more source

Identification and Synthesis of Selected In Vitro Generated Metabolites of the Novel Selective Androgen Receptor Modulator (SARM) 2f

Molecules, 2023
Among anabolic agents, selective androgen receptor modulators (SARMs) represent a new class of potential drugs that can exhibit anabolic effects on muscle and bone with reduced side effects due to a tissue-selective mode of action.
T. Möller, Hui-Chung Wen, Nana Naumann, O. Krug, M. Thevis   +4 more
semanticscholar   +1 more source

YK11 Induces Oxidative Stress and Mitochondrial Dysfunction in Hippocampus: The Interplay Between A Selective Androgen Receptor Modulator (SARM) and Exercise.

Journal of Steroid Biochemistry and Molecular Biology, 2023
Our study investigates potential neurochemical effects of (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), a selective androgen receptor modulator (SARM), in the rat hippocampus, with a
M. M. M. Dahleh, V. Bortolotto, G. Guerra, S. Boeira, M. Prigol   +4 more
semanticscholar   +1 more source