Results 11 to 20 of about 54,039 (182)

Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport [PDF]

npj Vaccines
Self-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Jason A. Wojcechowskyj, Robyn M. Jong, Imre Mäger, Britta Flach, Paul V. Munson, Progya P. Mukherjee, Barbara Mertins, Katherine R. Barcay, Thomas Folliard   +8 more
doaj   +2 more sources

Measuring the Level of Readiness in SDI Al-Hasaniah Students for Computer-Based Exams Using Technology Readiness Index Method

Jurnal Riset Informatika, 2023
The context of this research is that erratic rainfall can disrupt community activities, especially for traders who want to make sales. In addition, information about rainfall is also needed by farmers in determining planting patterns to get maximum ...
Anggi Oktaviani, Deny Novianti, Dahlia Sarkawi, Muhamad Zul Fahmi   +3 more
doaj   +1 more source

Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens

Poultry Science, 2023
: In order to minimize animal loss and economical loss, industrial poultry is heavily vaccinated against infectious agents. mRNA vaccination is an effective vaccination platform, yet little to no comprehensive, comparative studies in avians can be found.
Janne Snoeck, Koen Chiers, Ying Tam, Niek N. Sanders, An Garmyn   +4 more
doaj   +1 more source

Sarna Norueguesa

Acta Médica Portuguesa, 2013
Hugo Barreiros, João Alves, Pedro Serrano   +2 more
doaj   +2 more sources

Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines

Pharmaceutics, 2023
Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines.
Dylan Kairuz, Nazia Samudh, Abdullah Ely, Patrick Arbuthnot, Kristie Bloom   +4 more
doaj   +1 more source

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Molecular Therapy: Nucleic Acids, 2022
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy.
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou   +5 more
doaj   +1 more source

The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta

Scientific Reports, 2021
The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize severe acute
Reza Keikha, Seyed Mohammad Hashemi-Shahri, Ali Jebali   +2 more
doaj   +1 more source

Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccines.

PLoS Pathogens, 2022
The optimal vaccination strategy to boost responses in the context of pre-existing immune memory to the SARS-CoV-2 spike (S) glycoprotein is an important question for global public health.
Tamara Elliott, Hannah M Cheeseman, Abbey B Evans, Suzanne Day, Leon R McFarlane, Jessica O'Hara, Mohini Kalyan, Fahimah Amini, Tom Cole, Alan Winston, Sarah Fidler, Katrina M Pollock, James A Harker, Robin J Shattock   +13 more
doaj   +1 more source

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Molecular Therapy: Nucleic Acids, 2021
Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein ...
Yoann Aldon, Paul F. McKay, Jorge Moreno Herrero, Annette B. Vogel, Réka Lévai, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Heinrich Haas, Katalin Fábián, Roger Le Grand, Ugur Sahin, Robin J. Shattock   +11 more
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Progress in researches on self-amplifying RNA vaccines

Zhongguo gonggong weisheng, 2023
Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
doaj   +1 more source