A Self-amplifying mRNA vaccine for infectious laryngotracheitis virus (ILTV) induces efficient protective immunity [PDF]
Poultry ScienceInfectious laryngotracheitis (ILT) continues to pose a significant threat to intensive poultry farming regions worldwide. Current control strategies primarily rely on live attenuated and recombinant live ILT virus (ILTV) vaccines.
Huan-huan Li +11 more
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Molecular Therapy - Nucleic Acids, 2019 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease.
Kai-Wen Huang +2 more
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A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants [PDF]
npj VaccinesPseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity. We constructed a
Tong Ling +16 more
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Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer [PDF]
Oncogene, 2018 Liver diseases are a growing epidemic worldwide. If unresolved, liver fibrosis develops and can lead to cirrhosis and clinical decompensation. Around 5% of cirrhotic liver diseased patients develop hepatocellular carcinoma (HCC), which in its advanced stages has limited therapeutic options and negative survival outcomes.
Vikash Reebye +17 more
openaire +4 more sources
Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity [PDF]
eLifeSelf-amplifying RNA (saRNA) holds promise for durable therapeutic gene expression, but its broader utility beyond vaccines is limited by potent innate immune responses triggered during replication.
Tony KY Lim +6 more
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saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription
Cell Research, 2016 Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate gene expression at the transcriptional level, a phenomenon known as RNA activation (RNAa).
Long-Cheng Li +2 more
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Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities [PDF]
Advanced ScienceMessenger ribonucleic acid (mRNA)‐based therapies, including conventional linear mRNA (linRNA), circular RNA (circRNA), and self‐amplifying RNA (saRNA), are being developed not only for vaccination but also for protein replacement, gene editing, and ...
Irafasha C. Casmil +12 more
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Jurnal Riset Informatika, 2023 The context of this research is that erratic rainfall can disrupt community activities, especially for traders who want to make sales. In addition, information about rainfall is also needed by farmers in determining planting patterns to get maximum ...
Anggi Oktaviani +3 more
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Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens
Poultry Science, 2023 : In order to minimize animal loss and economical loss, industrial poultry is heavily vaccinated against infectious agents. mRNA vaccination is an effective vaccination platform, yet little to no comprehensive, comparative studies in avians can be found.
Janne Snoeck +4 more
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Pharmaceutics, 2023 Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines.
Dylan Kairuz +4 more
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