Results 21 to 30 of about 54,168 (197)
Molecular Therapy: Nucleic Acids, 2022 Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy.
Noelia Silva-Pilipich +5 more
doaj +1 more source
Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA
Molecular Therapy: Nucleic Acids, 2021 Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein ...
Yoann Aldon +11 more
doaj +1 more source
Progress in researches on self-amplifying RNA vaccines
Zhongguo gonggong weisheng, 2023 Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
doaj +1 more source
PLoS Pathogens, 2022 The optimal vaccination strategy to boost responses in the context of pre-existing immune memory to the SARS-CoV-2 spike (S) glycoprotein is an important question for global public health.
Tamara Elliott +13 more
doaj +1 more source
RNA Activation—A Novel Approach to Therapeutically Upregulate Gene Transcription
Molecules, 2021 RNA activation (RNAa) is a mechanism whereby RNA oligos complementary to genomic sequences around the promoter region of genes increase the transcription output of their target gene.
Choon Ping Tan +4 more
doaj +1 more source
C/EBPα Short-Activating RNA Suppresses Metastasis of Hepatocellular Carcinoma through Inhibiting EGFR/β-Catenin Signaling Mediated EMT. [PDF]
PLoS ONE, 2016 Hepatocellular carcinoma is associated with high mortality, and tumor metastasis is an important reason for poor prognosis. However, metastasis has not been effectively prevented in clinical therapy and the mechanisms underlying metastasis have not been ...
Hongbo Huan +7 more
doaj +1 more source
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]
, 2012 It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J +7 more
core +4 more sources
Revista médica (Colegio de Médicos y Cirujanos de Guatemala), 2020 La sarna noruega es una forma aguda de la sarna que se observa en pacientes inmunosupresos. A continuación se presenta el caso de un paciente de 73 años con antecedente de insuficiencia renal con diagnóstico de sarna noruega.
Rosmin Del Pilar Marroquín Remón +3 more
openaire +2 more sources
Scientific Reports, 2023 Self-amplifying messenger ribonucleic acid (saRNA) provides extended expression of genes of interest by encoding an alphavirus-derived RNA replicase and thus is 2–3 times larger than conventional messenger RNA.
Irafasha C. Casmil +2 more
doaj +1 more source
How Evolved are the Mass Donor Stars inCataclysmic Variables? [PDF]
, 2001 Recent spectroscopic observations have identified several cataclysmic variables non-solar metal abundances. We present theoretical models which examine the level of core evolution expected for CV secondaries prior to contact.
Howell, Steve B.
core +3 more sources