Results 11 to 20 of about 54,168 (197)

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities [PDF]

Advanced Science
Messenger ribonucleic acid (mRNA)‐based therapies, including conventional linear mRNA (linRNA), circular RNA (circRNA), and self‐amplifying RNA (saRNA), are being developed not only for vaccination but also for protein replacement, gene editing, and ...
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
doaj   +2 more sources

Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development [PDF]

Viruses
Self-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural ...
Thomas Vallet, Marco Vignuzzi
doaj   +2 more sources

A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses [PDF]

Frontiers in Immunology
IntroductionYellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date.
Peter Battisti, Matthew R. Ykema, Darshan N. Kasal, Madeleine F. Jennewein, Samuel Beaver, Abbie E. Weight, Derek Hanson, Jasneet Singh, Julie Bakken, Noah Cross, Pauline Fusco, Jacob Archer, Sierra Reed, Alana Gerhardt, Justin G. Julander, Corey Casper, Corey Casper, Corey Casper, Corey Casper, Emily A. Voigt   +19 more
doaj   +2 more sources

Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid

Journal of Nanobiotechnology
Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and a dismal prognosis. By targeting the underlying molecular abnormalities responsible for PDAC development and
Li Wang, Qunyan Yao, Xuerui Guo, Bingmei Wang, Jingyi Si, Xingye Wang, Shisong Jing, Ming Yan, Yan Shi, Guangqi Song, Xizhong Shen, Jiyu Guan, Yicheng Zhao, Changfeng Zhu   +13 more
doaj   +2 more sources

Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport [PDF]

npj Vaccines
Self-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Jason A. Wojcechowskyj, Robyn M. Jong, Imre Mäger, Britta Flach, Paul V. Munson, Progya P. Mukherjee, Barbara Mertins, Katherine R. Barcay, Thomas Folliard   +8 more
doaj   +2 more sources

Measuring the Level of Readiness in SDI Al-Hasaniah Students for Computer-Based Exams Using Technology Readiness Index Method

Jurnal Riset Informatika, 2023
The context of this research is that erratic rainfall can disrupt community activities, especially for traders who want to make sales. In addition, information about rainfall is also needed by farmers in determining planting patterns to get maximum ...
Anggi Oktaviani, Deny Novianti, Dahlia Sarkawi, Muhamad Zul Fahmi   +3 more
doaj   +1 more source

Sarna Norueguesa

Acta Médica Portuguesa, 2013
Hugo Barreiros, João Alves, Pedro Serrano   +2 more
doaj   +2 more sources

Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens

Poultry Science, 2023
: In order to minimize animal loss and economical loss, industrial poultry is heavily vaccinated against infectious agents. mRNA vaccination is an effective vaccination platform, yet little to no comprehensive, comparative studies in avians can be found.
Janne Snoeck, Koen Chiers, Ying Tam, Niek N. Sanders, An Garmyn   +4 more
doaj   +1 more source

"More" Artificial mRNAs: Beyond the Art of Nature. [PDF]

Adv Sci (Weinh)
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Cui Y, Fukui M, Ohno H, Saito H.
europepmc   +2 more sources

Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines

Pharmaceutics, 2023
Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines.
Dylan Kairuz, Nazia Samudh, Abdullah Ely, Patrick Arbuthnot, Kristie Bloom   +4 more
doaj   +1 more source