Results 11 to 20 of about 11,540 (164)

Small Activating RNAs: A Curated Database and an Overview of Rational Design Principles [PDF]

Molecules
RNA activation (RNAa), mediated by small activating RNAs (saRNAs), upregulates endogenous gene expression through recruitment of the Argonaute proteins to the promoter, natural antisense transcripts, or other noncoding RNAs. This mechanistically distinct
Petra Sušjan-Leite, Peter Pečan, Ana Godeša, Fabienne Ramona Caldana, Roman Jerala   +4 more
doaj   +2 more sources

The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta

Scientific Reports, 2021
The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize severe acute
Ali Jebali, Seyed Mohammad Hashemi-Shahri   +1 more
exaly   +2 more sources

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase [PDF]

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +2 more sources

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity [PDF]

Nature Communications
Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity.
Raul Y. Sanchez-David, Josephine Nemegeer, Hoang Duy Le, Eva Žusinaite, Livia Spiga, Amanda Gonçalves, John S. Tregoning, Andres Merits, Pierre V. Maillard   +8 more
doaj   +2 more sources

Mandibular Fracture in A 12‐Hour‐Old Neonate: Successful Conservative Management With Excellent Long‐Term Functional and Craniofacial Growth Outcomes [PDF]

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Neonatal mandibular fractures are exceptionally rare but can be successfully managed with timely conservative treatment and anatomical reduction. Despite severe birth‐related maxillofacial trauma, the neonatal mandible demonstrates remarkable regenerative capacity, allowing excellent long‐term mandibular growth, occlusion, function, and facial
Symon Guthua, Wambeti Twahir, Krishan Sarna, Khushboo Sonigra, Jane Kabutu   +4 more
wiley   +2 more sources

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis [PDF]

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +2 more sources

Continuous Purification of mRNA Produced by In Vitro Transcription Using High Performance Countercurrent Membrane Purification [PDF]

Biotechnology and Bioengineering, Volume 123, Issue 9, Page 2303-2311, September 2026.
ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang, Amin Javidanbardan, Ali Behboudi, Andrew L. Zydney   +3 more
wiley   +2 more sources

Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry [PDF]

Veterinary Quarterly
Vaccination is routinely used in industrial poultry to control infectious diseases. Vaccines based on mRNA and self-amplifying RNA (saRNA) are approved for human use, but research on their application in poultry is limited.
Janne Snoeck, Xiaole Cui, Pieter Vervaeke, Niek N. Sanders, An Garmyn   +4 more
doaj   +2 more sources

Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo [PDF]

Nature Communications
Self-amplifying mRNA (saRNA) vectors hold promise for the sustained expression of mRNA vaccines in vivo. However, their inherently high immunogenicity and low-fidelity replication—stemming from the RNA viral genome’s replication mechanisms—limit their ...
Zunyong Feng, Liuxi Chu, Qiang Li, Jing Zhou, Ping Wu, Xuanbo Zhang, Yuanbo Pan, Jianhua Zou, Qun Chen, Zhiliang Xu, Liang Yan, Yanjiao Huang, Xiaokun Li, Zhouguang Wang, Xiaoyuan Chen   +14 more
doaj   +2 more sources

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines [PDF]

Nature Communications
Self-amplifying mRNA vaccines use a viral replicase for self-amplification. It is currently unclear whether anti-replicase immunity occurs after saRNA vaccination, and whether such pre-existing anti-replicase immunity impacts the efficacy of subsequent ...
Xiaole Cui, Laura Amelinck, Oriane Gillon, João Paulo Portela Catani, Ya Gao, Qing Sun, Elisabeth De Sutter, Pieter Vervaeke, Janne Snoeck, Stefan Lienenklaus, Xavier Saelens, Zifu Zhong, Niek N. Sanders   +12 more
doaj   +2 more sources