Results 11 to 20 of about 10,552 (197)

Degradable glycopolymers for saRNA transfection

Polymer Chemistry, 2023
Gene delivery is a powerful technique that is often exploited in the treatment of several diseases.
Alessandra Monaco, Beatriz Dias Barbieri, Gokhan Yilmaz, Robin J. Shattock, C. Remzi Becer   +4 more
openaire   +2 more sources

Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid

Journal of Nanobiotechnology
Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and a dismal prognosis. By targeting the underlying molecular abnormalities responsible for PDAC development and
Li Wang, Qunyan Yao, Xuerui Guo, Bingmei Wang, Jingyi Si, Xingye Wang, Shisong Jing, Ming Yan, Yan Shi, Guangqi Song, Xizhong Shen, Jiyu Guan, Yicheng Zhao, Changfeng Zhu   +13 more
doaj   +2 more sources

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines [PDF]

Nature Communications
Self-amplifying mRNA vaccines use a viral replicase for self-amplification. It is currently unclear whether anti-replicase immunity occurs after saRNA vaccination, and whether such pre-existing anti-replicase immunity impacts the efficacy of subsequent ...
Xiaole Cui, Laura Amelinck, Oriane Gillon, João Paulo Portela Catani, Ya Gao, Qing Sun, Elisabeth De Sutter, Pieter Vervaeke, Janne Snoeck, Stefan Lienenklaus, Xavier Saelens, Zifu Zhong, Niek N. Sanders   +12 more
doaj   +2 more sources

Optimization of In Vitro Transcription by Design of Experiment to Achieve High Self-Amplifying RNA Integrity [PDF]

Vaccines
Background: Self-amplifying mRNA (saRNA) holds promising application prospects. However, due to the inclusion of a replicase sequence, its extended length leads to premature termination during in vitro transcription (IVT), resulting in poor product ...
Chaoying Hu, Haixin Wang, Guanxing Liu, Kelei Li, Xuanxuan Zhang, Lifang Song, Fan Gao, Xing Wu, Qian Wang, Mingchen Liu, Jianyang Liu, Zhihao Fu, Xiao Ma, Miao Xu, Qunying Mao, Zhenglun Liang, Qian He   +16 more
doaj   +2 more sources

Sarna Noruega

Revista de la Facultad de Ciencias Médicas de Córdoba, 2018
La sarna noruega es una forma especial de escabiosis, infección cutánea producida por el Sarcoptes scabiei, infrecuente y muy contagiosa que afecta principalmente a pacientes inmunodeprimidos, ancianos e institucionalizados.
Hora Matias Castro, Maite Lisa Eliceche
doaj   +4 more sources

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

ACS Nano, 2020
Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA (mRNA), thus minimizing the required dose.
Paul Mckay, Clement Bouton, Christopher Grigsby   +2 more
exaly   +2 more sources

Development of a multi-epitope vaccine against Helicobacter pylori using a novel saRNA technology through an immunoinformatics approach. [PDF]

Sci Rep
The development of a vaccine against Helicobacter pylori remains a public health priority due to its role in various gastric and non-gastric diseases, compounded by the rise of antibiotic resistance. To address the urgent need for novel interventions, we
Razzak A, Ahmed F, Mahmud MT.
europepmc   +2 more sources

Safety and Immunogenicity of a Modified Self-Amplifying Ribonucleic Acid (saRNA) Vaccine Encoding SARS-CoV-2 Spike Glycoprotein in SARS-CoV-2 Seronegative and Seropositive Ugandan Individuals

Vaccines
Background: The COVID-19 pandemic highlighted the need for innovative vaccine platforms that elicit durable immunity. Self-amplifying RNA (saRNA) vaccines offer rapid production and dose-sparing advantages over traditional mRNA platforms.
Hannah Cheeseman, Benjamin Pierce, Jennifer Serwanga   +2 more
exaly   +2 more sources

Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA

Journal of Controlled Release, 2019
Self-amplifying RNA (saRNA) is well suited as a vaccine platform against chlamydia, as it is relatively affordable and scalable, has been shown to induce immunity against multivalent antigens, and can result in protein expression for up to 60 days ...
Paul Mckay, Yoann Aldon, Robin Shattock   +2 more
exaly   +2 more sources

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Gene Therapy, 2019
Self-amplifying RNA (saRNA) is a promising biotherapeutic tool that has been used as a vaccine against both infectious diseases and cancer. saRNA has been shown to induce protein expression for up to 60 days and elicit immune responses with lower dosing ...
Paul Mckay, Yoann Aldon, Robin Shattock   +2 more
exaly   +2 more sources