Results 41 to 50 of about 611 (156)

Factors influencing feline antiparasitic prescriptions by veterinarians and demographics across parts of the UK. [PDF]

Vet Rec Open
Abstract Background Antiparasitic drugs used in companion animals may persist in the environment, contributing to ecological contamination and raising One Health concerns. Understanding behavioural patterns of veterinarians’ prescription is essential for development of effective antiparasitic stewardship programmes. Methods A survey of 29 questions was
Hobbs RE, Duszak-Kowal A.
europepmc   +2 more sources

Safety and efficacy assessment of a chewable tablet containing sarolaner, moxidectin, and pyrantel in the treatment of Angiostrongylus vasorum in dogs

Veterinary Parasitology
Angiostrongylosis, caused by Angiostrongylus vasorum, is an important clinical disease in dogs in Europe with infection transmitted through infected snails and slugs which function as intermediate hosts. Previous studies demonstrated the preventive efficacy of a monthly administration of moxidectin in combination with sarolaner and pyrantel (Simparica ...
Lloyd, Anne, Van Mechelen, Lore, Van Overloop, Carleen, Doherty, Padraig, Willesen, Jakob L., Basano, Fabrizio Solari, Geurden, Thomas   +6 more
openaire   +4 more sources

Safety and efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment and control of naturally occurring flea infestations in cats presented as veterinary patients in Australia

Parasites & Vectors, 2020
Background The safety and efficacy of a new spot-on formulation of selamectin plus sarolaner were evaluated for the treatment and control of natural flea infestations on cats in two non-randomised, multi-centre clinical trials conducted in 8 different ...
Raj Packianathan, Melissa Pittorino, Andrew Hodge, Natalie Bruellke, Kelly Graham   +4 more
doaj   +1 more source

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

Bayesian multivariate longitudinal model for immune responses to Leishmania: A tick‐borne co‐infection study

Statistics in Medicine, Volume 42, Issue 21, Page 3860-3876, 20 September 2023., 2023
Abstract While many Bayesian state‐space models for infectious disease processes focus on population infection dynamics (eg, compartmental models), in this work we examine the evolution of infection processes and the complexities of the immune responses within the host using these techniques.
Felix M. Pabon‐Rodriguez, Grant D. Brown, Breanna M. Scorza, Christine A. Petersen   +3 more
wiley   +1 more source

Reduced incidence of tick paralysis cases in dogs and cats at two emergency clinics in South‐East Queensland since 2015: new generation prophylactics as possible explanatory variables

Australian Veterinary Journal, Volume 101, Issue 9, Page 356-365, September 2023., 2023
Introduction This study aimed to determine the incidence of canine and feline tick paralysis cases presenting to two veterinary emergency hospitals before and after the introduction of new generation prophylactic acaricides. Methods This was a retrospective study, investigating the number of tick paralysis cases presenting to two emergency and critical
EM Ireland, J Heller, EM Leister, AM Padula   +3 more
wiley   +1 more source

Biological variation of biochemical urine and serum analytes in healthy dogs

Veterinary Clinical Pathology, Volume 52, Issue 3, Page 461-474, September 2023., 2023
Abstract Background Biological variation (BV) of urinary (U) biochemical analytes has not been described in absolute terms, let alone as a ratio of the U‐creatinine or fractional excretion in healthy dogs. These analytes are potential diagnostic tools for different types of kidney damage and electrolyte disorders in dogs.
Anna K. Selin, Inger Lilliehöök, Johannes Forkman, Anders Larsson, Lena Pelander, Emma M. Strage   +5 more
wiley   +1 more source

Canine and feline P‐glycoprotein deficiency: What we know and where we need to go

Journal of Veterinary Pharmacology and Therapeutics, Volume 46, Issue 1, Page 1-16, January 2023., 2023
Abstract In 2001 the molecular genetic basis of so‐called “ivermectin sensitivity” in herding breed dogs was determined to be a P‐glycoprotein deficiency caused by a genetic variant of the MDR1 (ABCB1) gene often called “the MDR1 mutation.” We have learned a great deal about P‐glycoprotein's role in drug disposition since that discovery, namely that P ...
Katrina L. Mealey, Jane G. Owens, Elaine Freeman   +2 more
wiley   +1 more source

Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1‐deficient collie dogs

Journal of Veterinary Pharmacology and Therapeutics, Volume 45, Issue 4, Page 373-379, July 2022., 2022
Abstract Afoxolaner, an insecticide and acaricide compound of the isoxazoline class, is available for dogs as an oral ectoparasiticide medicine (NexGard®) and as an oral endectoparasiticide medicine in combination with milbemycin oxime (MO), a macrocyclic lactone (NexGard® Spectra).
Marlene Drag, Eric Tielemans, Elizabeth Mitchell   +2 more
wiley   +1 more source

New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Elgueta I, Lewis D, Morgan ER, Helm J.
europepmc   +2 more sources