Results 41 to 50 of about 10,200,147 (283)

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Molecules, 2021
Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic ...
Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu, Milan Stefek   +5 more
doaj   +1 more source

A new look at reflection seismic data from the Central Caledonian Transect across the Scandinavian Peninsula [PDF]

Solid Earth
This study revisits seismic reflection data from the Central Scandinavian Caledonides, initially acquired during campaigns in the late 1980s and early 1990s.
C. Juhlin, R. Lescoutre, B. Almqvist
doaj   +1 more source

Topographic characteristics after Descemet's membrane endothelial keratoplasty and Descemet's stripping automated endothelial keratoplasty. [PDF]

PLoS ONE, 2017
To investigate the topographic characteristics of the posterior corneal surface after Descemet's endothelial membrane keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK) and their effects on postoperative visual acuity.
Takahiko Hayashi, Takefumi Yamaguchi, Kentaro Yuda, Naoko Kato, Yoshiyuki Satake, Jun Shimazaki   +5 more
doaj   +1 more source

Superfluidity in multicomponent fermions via the functional renormalization group

Nuclear Physics B, 2023
We reveal the critical properties of the phase transition towards superfluid order that has been proposed to occur in large spin fermionic systems. For this purpose, we consider the bosonic field theory for fluctuations of the complex skew-symmetric rank-
Michal Hnatič, Georgii Kalagov
doaj   +1 more source

Nyelvtanulással kapcsolatos statisztikai vizsgálatok SAS szoftverek segítségével

, 2021
Szakdolgozatomban a SAS világszerte ismert két szoftverét szeretném bemutatni és alkalmazni: a SAS Enterprise Guide-ot, illetve a SAS Enterprise Miner-t idegen nyelv tanulással kapcsolatos statisztikai vizsgálatokon keresztül.
Vasadi, Boglárka
core  

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

Life Science Alliance
We have found that the overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway.
Eleanor Hargreaves, Rebecca Collinson, Andrew D Jenks, Adina Staszewski, Athanasios Tsalikis, Raquel Bodoque, Mar Arias-Garcia, Yasmin Abdi, Abdulaziz Al-Malki, Yinyin Yuan, Rachael Natrajan, Syed Haider, Thomas Iskratsch, Won-Jing Wang, Susana Godinho, Nicolaos J Palaskas, Fernando Calvo, Igor Vivanco, Tobias Zech, Barbara E Tanos   +19 more
doaj   +1 more source

SAS-6 Association with γ-Tubulin Ring Complex Is Required for Centriole Duplication in Human Cells [PDF]

Current Biology, 2020
Centrioles are essential components of centrosome, the main microtubule-organizing center of animal cells required for robust spindle bipolarity [1, 2]. They are duplicated once during the cell cycle [3], and the duplication involves assembly of a cartwheel on the pre-existing centriole followed by assembly of triplet microtubules around the cartwheel [
Hindol, Gupta, Resmi, Rajeev, Ranjan, Sasmal, Renjith M, Radhakrishnan, Ushma, Anand, Haritha, Chandran, Nurni R, Aparna, Sarit, Agasti, Tapas K, Manna   +8 more
openaire   +2 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source