Results 31 to 40 of about 10,200,147 (283)

Barriers to brain health behaviours: results from the Five Lives Brain Health Ireland Survey

Frontiers in Psychology, 2023
Modifiable risk factors for dementia remain prevalent in Ireland. A detailed examination of barriers to risk reduction behaviours in an Irish context has heretofore been lacking. Many existing studies examining barriers to brain health behaviours fail to
Tim Dukelow, Philip Vassilev, Erin Grace Lawrence, Erin Grace Lawrence, Liron Jacobson, Ivan Koychev, Ivan Koychev, Kinan Muhammed, Sean P. Kennelly, Sean P. Kennelly   +9 more
doaj   +1 more source

SAS-6 oligomerization: the key to the centriole?

Nature Chemical Biology, 2011
Centrioles are among the most beautiful of biological structures. How their highly conserved nine-fold symmetry is generated is a question that has intrigued cell biologists for decades. Two recent structural studies provide the tantalizing suggestion that the self-organizing properties of the SAS-6 protein hold the answer.
Cottee, M, Raff, J, Lea, S, Roque, H
openaire   +3 more sources

Phosphorylation of SAS-6 by ZYG-1 Is Critical for Centriole Formation in C. elegans Embryos [PDF]

Developmental Cell, 2009
Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for centrosome duplication. In Caenorhabditis elegans embryos, the proteins SPD-2, ZYG-1, SAS-6, SAS-5,
Kitagawa, Daiju, Busso, Coralie, Fluckiger, Isabelle, Gönczy, Pierre   +3 more
openaire   +4 more sources

Identification and localization of SAS-6 in the microsporidium Nosema bombycis

Infection, Genetics and Evolution, 2019
The centriole in eukaryotes functions as the cell's microtubule-organizing center (MTOC) to nucleate spindle assembly. The evolutionarily conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis.
Weijiang, Dai, Nan, Li, Zhilin, Zhang, Gong, Chen, Xiaoliang, Li, Xiangran, Peng, Yiling, Zhang, Li, Xu, Zhongyuan, Shen   +8 more
openaire   +2 more sources

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture [PDF]

Nature Cell Biology, 2016
Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS-6-based oligomers with symmetries ranging from five- to ten-fold.
Hilbert, Manuel, Noga, Akira, Frey, Daniel, Hamel, Virginie, Guichard, Paul, Kraatz, Sebastian H. W., Pfreundschuh, Moritz, Hosner, Sarah, Fluckiger, Isabelle, Jaussi, Rolf, Wieser, Mara M., Thieltges, Katherine M., Deupi, Xavier, Muller, Daniel, Kammerer, Richard A., Gonczy, Pierre, Hirono, Masafumi, Steinmetz, Michel O.   +17 more
openaire   +3 more sources

Protein expression and subcellular distribution of centriolar component SAS-6 in mouse oocyte meiosis [PDF]

Jichu yixue yu linchuang
Objective To study the expression and subcellular distribution pattern of centriolar protein SAS-6 during meiosis of mouse oocytes. Methods Immunefluorescence was conducted to analyze the subcellular distribution pattern of SAS-6 in Chinese hamster ...
SONG Ke, SONG Ke, LI Jingyu, MA Wei, YANG Xiaokui
doaj   +1 more source

Surgical Apgar score as a predictor of outcomes in patients following laparotomy at Mulago National Referral Hospital, Uganda: a prospective cohort study

BMC Surgery, 2022
Background Postoperative complications and mortality following laparotomy have remained high worldwide. Early postoperative risk stratification is essential to improve outcomes and clinical care.
Bruno Chan Onen, Andrew Weil Semulimi, Felix Bongomin, Ronald Olum, Gideon Kurigamba, Ronald Mbiine, Olivia Kituuka   +6 more
doaj   +1 more source

The Surgical Apgar Score can help predict postoperative complications in femoral neck fracture patients: a 6-year retrospective cohort study

JA Clinical Reports, 2018
Introduction The postoperative mortality rate following a femoral neck fracture remains high. The Surgical Apgar Score (SAS), based on intraoperative blood loss, the lowest mean arterial pressure, and the lowest heart rate, was created to predict 30-day ...
Atsushi Kotera
doaj   +1 more source

Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. [PDF]

Proc Natl Acad Sci U S A, 2013
Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family.
Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Flückiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gönczy P, Vakonakis I.   +11 more
europepmc   +6 more sources

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

eLife, 2015
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic ...
Kacper B Rogala, Nicola J Dynes, Georgios N Hatzopoulos, Jun Yan, Sheng Kai Pong, Carol V Robinson, Charlotte M Deane, Pierre Gönczy, Ioannis Vakonakis   +8 more
doaj   +1 more source