Results 11 to 20 of about 10,200,147 (283)
Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. [PDF]
Dev Cell, 2013 SummaryAssembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase activity is subsequently required for cartwheel ...
Lettman MM +8 more
europepmc +5 more sources
Structures of SAS-6 suggest its organization in centrioles.
Science, 2011 Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella.
van Breugel, M +38 more
core +6 more sources
DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6 [PDF]
Nature Communications, 2017 Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu +9 more
doaj +2 more sources
Re-engineering Caenorhabditis elegans SAS-6: from spirals to rings [PDF]
, 2019 Centrioles have conserved 9-fold symmetry. This symmetry is templated by a scaffold of SAS-6. SAS-6 oligomerises to form a stack of rings, each with 9-fold radial symmetry, that forms the cartwheel, which imparts symmetry to the organelle.
Jodie Ford, Ford, Jodie
core +2 more sources
Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization. [PDF]
J Biol Chem, 2020 Centrioles are key eukaryotic organelles that are responsible for the formation of cilia and flagella, and for organizing the microtubule network and the mitotic spindle in animals. Centriole assembly requires oligomerization of the essential protein spindle assembly abnormal 6 (SAS-6), which forms a structural scaffold templating the organization of ...
Busch JMC +5 more
europepmc +5 more sources
Generation of sas-6::ha by CRISPR/Cas9 editing. [PDF]
MicroPubl Biol, 2019 Centrosomes are comprised of a pair of barrel-shaped centrioles that are oriented at right angles to each other, and embedded in electron dense pericentriolar material. The centrosomes mediate spindle assembly and function as basal bodies to promote cilia and flagella formation (reviewed in Pintard and Bowerman, 2019 and Fırat-Karalar and Stearns, 2014)
Bergwell M +4 more
europepmc +3 more sources
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel. [PDF]
Structure, 2022 Centrioles are eukaryotic organelles that template the formation of cilia and flagella, as well as organize the microtubule network and the mitotic spindle in animal cells. Centrioles have proximal-distal polarity and a 9-fold radial symmetry imparted by a likewise symmetrical central scaffold, the cartwheel.
Kantsadi AL +3 more
europepmc +4 more sources
The PLK4-STIL-SAS-6 module at the core of centriole duplication. [PDF]
Biochem Soc Trans, 2016 Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited.
Arquint C, Nigg EA.
europepmc +8 more sources
International Journal for Parasitology: Parasites and Wildlife, 2023 Toxoplasma gondii is an intracellular protozoon found worldwide, which completes its life cycle between felids (its definitive host) and other warm-blooded animals.
François Fasquelle +5 more
doaj +1 more source
Antibodies, 2023 Human respiratory syncytial virus (hRSV) is one of the major contagious viruses and causes complicated respiratory issues, especially in young children. The sensitive and fast detection of hRSV is critical for taking the most effective actions.
Pierre-Emmanuel Baurand +5 more
doaj +1 more source