Angewandte Chemie, EarlyView.The engineered DTSe‐based photosensitizer, DZTSe, emerges as an avant‐garde molecular entity, which can distribute to both the endoplasmic reticulum and mitochondria to concurrently trigger pyroptosis and activate the cGAS‐STING pathway. This dual‐action strategy effectively reprograms the tumor microenvironment, enabling potent eradication of primary ...
Cheng Zhang +7 more
wiley +2 more sources
Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells. [PDF]
J Bone Miner ResYeo D +4 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto +6 more
wiley +2 more sources
Long-read genome assembly of the insect model organism <i>Tribolium castaneum</i> reveals spread of satellite DNA in gene-rich regions by recurrent burst events. [PDF]
Genome ResVolarić M +4 more
europepmc +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
The Satellite DNA PcH-Sat, Isolated and Characterized in the Limpet Patella caerulea (Mollusca, Gastropoda), Suggests the Origin from a Nin-SINE Transposable Element. [PDF]
Genes (Basel)Petraccioli A +4 more
europepmc +1 more source
A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants
Applications in Plant Sciences, EarlyView.Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk +6 more
wiley +1 more source
Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs
The Anatomical Record, EarlyView.Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy +3 more
wiley +1 more source