Results 41 to 50 of about 50,612 (210)
Nature CommunicationsHuman kinetochores assemble onto centromeric DNA comprising repetitive arrays of the 171 bp α-satellite sequence. To understand the higher-order architecture of the inner kinetochore assembled onto α-satellite arrays, we show cryo-EM structures of CCAN ...
Cong Yu +5 more
doaj +1 more source
Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery
Advanced Functional Materials, EarlyView.This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar +4 more
wiley +1 more source
DNA Environment of Centromeres and Non-Homologous Chromosomes Interactions in Mouse
Cells, 2021 Although the pericentromeric regions of chromosomes that are enriched in tandemly repeated satellite DNA represent a significant part of eukaryotic genomes, they remain understudied, which is mainly due to interdisciplinary knowledge gaps. Recent studies
Victor Spangenberg +5 more
doaj +1 more source
Make‐Use‐Remake: Toward Indefinite Low‐Temperature Material Loops
Advanced Functional Materials, EarlyView.We introduce a regenerable materials platform built from microparticles bound by a temperature‐responsive polymer shell, enabling strong, processable structures from diverse feedstocks. The material is shaped at low temperatures (80°C) using common manufacturing methods and reprocessed repeatedly in the presence of water, demonstrating stable ...
Nikola Křivánková +2 more
wiley +1 more source
Defective transcription of AAGAG satellite DNA causes sex-ratio meiotic drive in Drosophila
Nature CommunicationsMale germ cells have complex transcriptomes, with a large fraction of the genome being transcribed. This includes protein-coding genes (often not translated), non-coding DNA, and repetitive DNA, such as transposons and satellite DNA, which are normally ...
Tomohiro Kumon +5 more
doaj +1 more source
Protective role of γ ⁃ tocotrienol on muscle satellite cells of Duchenne muscular dystrophy in mice
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Objective To investigate the damage of skeletal muscle satellite cells in Duchenne muscular dystrophy (DMD) and the protective effect of γ⁃tocotrienol (GT3) on muscle satellite cells in DMD knockout mice.
YANG Shuo +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Satellite DNA Modulates Gene Expression in the Beetle Tribolium castaneum after Heat Stress. [PDF]
PLoS Genetics, 2015 Non-coding repetitive DNAs have been proposed to perform a gene regulatory role, however for tandemly repeated satellite DNA no such role was defined until now.
Isidoro Feliciello +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source
Defining a core configuration for human centromeres during mitosis
Nature Communications, 2023 The centromere components cohesin, CENP-A, and centromeric DNA are essential for biorientation of sister chromatids on the mitotic spindle and accurate sister chromatid segregation.
Ayantika Sen Gupta +7 more
doaj +1 more source