Results 1 to 10 of about 126 (114)

The modular mechanism of chromocenter formation in Drosophila

eLife, 2019
A central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. Previously we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known ...
Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita   +2 more
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Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells.

PLoS Genetics, 2021
Pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions, plays crucial roles in various cellular events, such as cell division and DNA replication.
Yota Hagihara, Satoshi Asada, Takahiro Maeda, Toru Nakano, Shinpei Yamaguchi   +4 more
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EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science
Eukaryotic translation initiation factor 5A (eIF5A) facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood.
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
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Mouse chromocenters DNA content: sequencing and in silico analysis [PDF]

BMC Genomics, 2018
Background Chromocenters are defined as a punctate condensed blocks of chromatin in the interphase cell nuclei of certain cell types with unknown biological significance.
Dmitrii I. Ostromyshenskii, Ekaterina N. Chernyaeva, Inna S. Kuznetsova, Olga I. Podgornaya   +3 more
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Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction

Nucleus
Aberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Gianna Manning, Andy Li, Nebiyat Eskndir, Marilena Currey, Andrew D. Stephens   +4 more
doaj   +3 more sources

A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation

Nucleic Acids Research, 2020
AbstractDuring interphase centromeres often coalesce into a small number of chromocenters, which can be visualized as distinct, DAPI dense nuclear domains. Intact chromocenters play a major role in maintaining genome stability as they stabilize the transcriptionally silent state of repetitive DNA while ensuring centromere function.
Axel Imhof, Andreas W Thomae, Aloys Schepers, Andrew Flatley, Andreas Schmidt, Andrea Lukacs, Grusha Primal Mathias, Tamas Schauer, Natalia Y Kochanova   +8 more
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Relationship of chromocenter number, size, and density to plant biomass

Caryologia, 1996
SUMMARYA variety of plant species and cultivars were stained for chromocenters using the barium hydroxide, sodium saline citrate (SSC), Giemsa procedure (DNA denaturation, incubation-renaturation, staining), in order to test the hypothesis that larger (biomass) species have larger, more numerous, and more intensely-staining chromocenters.
Jack R. Edelman, Yue J. Lin
openaire   +3 more sources

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells [PDF]

ACS Chemical Biology, 2021
Abstract Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated ‘reader’ proteins.
Guidotti, Nora, Eördögh, Ádám, Mivelaz, Maxime, Rivera-Fuentes, Pablo, Fierz, Beat   +4 more
openaire   +5 more sources

DNA Environment of Centromeres and Non-Homologous Chromosomes Interactions in Mouse

Cells, 2021
Although the pericentromeric regions of chromosomes that are enriched in tandemly repeated satellite DNA represent a significant part of eukaryotic genomes, they remain understudied, which is mainly due to interdisciplinary knowledge gaps. Recent studies
Victor Spangenberg, Mikhail Losev, Ilya Volkhin, Svetlana Smirnova, Pavel Nikitin, Oxana Kolomiets   +5 more
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Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators.

PLoS Genetics, 2021
Reduction of genome ploidy from diploid to haploid necessitates stable pairing of homologous chromosomes into bivalents before the start of the first meiotic division.
Luisa Vernizzi, Christian F Lehner
doaj   +1 more source