Results 1 to 10 of about 6,135 (207)
A conserved function for pericentromeric satellite DNA
eLife, 2018 A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown.
Madhav Jagannathan +2 more
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G3: Genes, Genomes, Genetics, 2017 Microscopically visible chromatin is partitioned into two major components in Arabidopsis thaliana nuclei. On one hand, chromocenters are conspicuous foci of highly condensed “heterochromatic” domains that contain mostly repeated sequences.
Basten L. Snoek +8 more
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eLife, 2018 Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.
Susan A Gerbi
doaj +1 more source
NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects
BMC Bioinformatics, 2022 Background The three-dimensional nuclear arrangement of chromatin impacts many cellular processes operating at the DNA level in animal and plant systems.
Tristan Dubos +8 more
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bioRxiv, 2018 In higher eukaryotes centromeres often coalesce into a large intranuclear domain called the chromocenter. Chromocenters are important for the organization of pericentric heterochromatin and a disturbance of their formation results in an upregulation of ...
N. Y. Kochanova +8 more
semanticscholar +1 more source
High-resolution mapping of h1 linker histone variants in embryonic stem cells. [PDF]
PLoS Genetics, 2013 H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that ...
Kaixiang Cao +15 more
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HAC stability in murine cells is influenced by nuclear localization and chromatin organization
BMC Cell Biology, 2009 Background Human artificial chromosomes (HAC) are small functional extrachromosomal elements, which segregate correctly during each cell division. In human cells, they are mitotically stable, however when the HAC are transferred to murine cells they show
Volpi Emanuela V +4 more
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Tissue-specific differences in the spatial interposition of X-chromosome and 3R chromosome regions in the malaria mosquito Anopheles messeae Fall. [PDF]
PLoS ONE, 2015 Spatial organization of a chromosome in a nucleus is very important in biology but many aspects of it are still generally unresolved. We focused on tissue-specific features of chromosome architecture in closely related malaria mosquitoes, which have ...
Gleb Artemov +3 more
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Cell Death and Disease, 2015 The Berardinelli–Seip congenital lipodystrophy type 2 (Bscl2, seipin) gene is involved in adipogenesis. Bscl2−/− males were infertile but had normal mating behavior.
A. E. El Zowalaty +5 more
semanticscholar +1 more source
Neurobiology of Disease, 2011 Mutations in MECP2, encoding methyl CpG binding protein 2, cause the neurodevelopmental disorder Rett syndrome. MeCP2 is an abundant nuclear protein that binds to chromatin and modulates transcription in response to neuronal activity.
Malaika K. Singleton +6 more
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