Results 31 to 40 of about 126 (114)

Role of dynamic nuclear deformation on genomic architecture reorganization.

PLoS Computational Biology, 2019
Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals.
Sungrim Seirin-Lee, Fumitaka Osakada, Junichi Takeda, Satoshi Tashiro, Ryo Kobayashi, Takashi Yamamoto, Hiroshi Ochiai   +6 more
doaj   +1 more source

CUT&Tag for High‐Resolution Epigenomic Profiling From a Low Amount of Arabidopsis Tissue

Plant Direct, Volume 10, Issue 4, April 2026.
ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regulations of gene expression, both in animal and plant systems.
Yixuan Fu, Marc W. Schmid, Sara Simonini   +2 more
wiley   +1 more source

Polyploidy and the Cellular and Areal Diversity of Rat Cortical Layer 5 Pyramidal Neurons

Cell Reports, 2017
In many species, polyploidy, in which an increase in nuclear DNA content is accompanied by an increase in cell size, contributes to cellular diversity.
Johanna Sigl-Glöckner, Michael Brecht
doaj   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Spatial organization of fibroblast nuclear chromocenters: component tree analysis

Journal of Anatomy, 2013
AbstractThe nuclei of mouse connective tissue fibroblasts contain chromocenters which are well‐defined zones of heterochromatin that can be used as positional landmarks to examine nuclear remodeling in response to a mechanical perturbation. This study used component tree analysis, an image segmentation algorithm that detects high intensity voxels that ...
Robert R, Snapp, Elyse, Goveia, Lindsay, Peet, Nicole A, Bouffard, Gary J, Badger, Helene M, Langevin   +5 more
openaire   +3 more sources

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Comparative Study of Spermatogenesis and Nucleolar Behavior in Testicular Lobes of Euschistus heros (Heteroptera: Pentatomidae)

Psyche: A Journal of Entomology, 2010
In some testicular lobes of the Pentatomidae there may be occurrence of atypical spermatogenesis or polymegaly, leading to the production of nonfertile sperm.
Hederson Vinicius de Souza, Mary Massumi Itoyama   +1 more
doaj   +1 more source

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ethanol exposure alters brain endothelial cell function and blood–brain barrier integrity. In human brain microcapillary endothelial cells (HBMEC) and mouse brain endothelial cells (MBEC) from a prenatal alcohol exposure (PAE) model, ethanol increased DNA methyltransferas‐1 (DNMT1) activity and reduced DNA methylation, affecting DNMT3a/3b, methyl‐CpG ...
Michele Siqueira, Matheus Barros, Paula Lacerda Almeida, Luiza dos Santos Heringer, Henrique Rocha Mendonça, Flávia Carvalho Alcantara Gomes, Joice Stipursky   +6 more
wiley   +1 more source

Cytogenetics and cytotaxonomy of some Brazilian species of Cymbidioid orchids

Genetics and Molecular Biology, 2000
The Cymbidioid phylad presents the widest chromosome number variation among orchids, with records varying from 2n = 10 in Psygmorchis pusilla to 2n = 168 in two species of Oncidium.
Leonardo Pessoa Félix, Marcelo Guerra
doaj   +1 more source

Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis

BioEssays, Volume 48, Issue 1, January 2026.
The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley   +1 more source