Results 51 to 60 of about 6,135 (207)

Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. [PDF]

PLoS ONE, 2014
The human ATRX gene encodes hATRX, a chromatin-remodeling protein harboring an helicase/ATPase and ADD domains. The ADD domain has two zinc fingers that bind to histone tails and mediate hATRX binding to chromatin.
Brenda López-Falcón, Silvia Meyer-Nava, Benjamín Hernández-Rodríguez, Adam Campos, Daniel Montero, Enrique Rudiño, Martha Vázquez, Mario Zurita, Viviana Valadez-Graham   +8 more
doaj   +1 more source

Arabidopsis WSS1A, a DNA‐protein crosslink repair protease, delays leaf senescence in cooperation with SUMO3

The Plant Journal, Volume 127, Issue 4, August 2026.
SUMMARY Leaf senescence, the final stage of leaf development, is regulated by complex interplays of intrinsic genetic programs and environmental cues. Throughout their lifetimes, all living organisms encounter various endogenous and environmental challenges, many of which can cause potentially fatal DNA damage. Among these, DNA‐protein crosslinks (DPCs)
Sanghoon Park, Hyunwoo Oh, Ukcheol Jeong, Jae Ho Lee, Hyeyoung Choi, Hyunsu Park, Jinkwang Kim, Yongmin Kim, Junmin Kwak, Yeong Seon Yoon, Zhonghai Li, Jong‐Chan Lee, Hye Ryun Woo   +12 more
wiley   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, Volume 83, Issue 6, Page 354-375, June 2026.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

CUT&Tag for High‐Resolution Epigenomic Profiling From a Low Amount of Arabidopsis Tissue

Plant Direct, Volume 10, Issue 4, April 2026.
ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regulations of gene expression, both in animal and plant systems.
Yixuan Fu, Marc W. Schmid, Sara Simonini   +2 more
wiley   +1 more source

Chromocenter adjacent enrichment of AtMORC4 and AtMORC7 in the nucleus.

, 2016
(A-D) Representative examples of body forming AtMORC7-MYC, AtMORC4-MYC, At-MORC1-MYC, and AtMORC6-MYC nuclei, respectively. (E) Untransformed wt nucleus subjected to the same antibody staining and imaging procedure. Left panels = anti-MYC channel; middle
C. Jake Harris (3171039), Jeffery L. Dangl (24084), Wanlu Liu (782239), Ajay A. Vashisht (128117), Steven E. Jacobsen (116800), Dylan Husmann (3171033), William A. Pastor (367541), Guillaume Moissiard (3171042), Ashot Papikian (3171030), James A. Wohlschlegel (212752), Farid El Kasmi (3171036), Haifeng Wang (188956)   +11 more
core   +1 more source

Contribution of AT-, GC-, and methylated cytidine-rich DNA to chromatin composition in Malpighian tubule cell nuclei of Panstrongylus megistus (hemiptera, Reduviidae)

, 2015
The Malpighian tubule cell nuclei of male Panstrongylus megistus, a vector of Chagas disease, contain one chromocenter, which is composed solely of the Y chromosome. Considering that different chromosomes contribute to the composition of chromocenters in
Mondin, Mateus, Rodrigues, Vera L.C.C., Andrade, Larissa M., Vidal, Benedicto de Campos, Alvarenga, Elenice M., Rodrigues, Vera L. C. C., Mello, Maria Luiza S.   +6 more
core   +2 more sources

Role of dynamic nuclear deformation on genomic architecture reorganization.

PLoS Computational Biology, 2019
Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals.
Sungrim Seirin-Lee, Fumitaka Osakada, Junichi Takeda, Satoshi Tashiro, Ryo Kobayashi, Takashi Yamamoto, Hiroshi Ochiai   +6 more
doaj   +1 more source

Spatial organization of fibroblast nuclear chromocenters: component tree analysis

Journal of Anatomy, 2013
AbstractThe nuclei of mouse connective tissue fibroblasts contain chromocenters which are well‐defined zones of heterochromatin that can be used as positional landmarks to examine nuclear remodeling in response to a mechanical perturbation. This study used component tree analysis, an image segmentation algorithm that detects high intensity voxels that ...
Robert R, Snapp, Elyse, Goveia, Lindsay, Peet, Nicole A, Bouffard, Gary J, Badger, Helene M, Langevin   +5 more
openaire   +3 more sources

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Polyploidy and the Cellular and Areal Diversity of Rat Cortical Layer 5 Pyramidal Neurons

Cell Reports, 2017
In many species, polyploidy, in which an increase in nuclear DNA content is accompanied by an increase in cell size, contributes to cellular diversity.
Johanna Sigl-Glöckner, Michael Brecht
doaj   +1 more source