Results 41 to 50 of about 126 (114)

Changes in nuclear phenotypes following cold shock in Panstrongylus megistus (Burmeister)

Memorias do Instituto Oswaldo Cruz, 2000
The nuclear phenotypes of Malpighian tubule epithelial cells of 5th instar male nymphs of the blood-sucking insect Panstrongylus megistus were studied immediately after a short (1 h) cold shock at 0ºC, and 10 and 30 days later.
Simone L Garcia, Maria Luiza S Mello, Nancy L Garcia, Vera Lúcia CC Rodrigues   +3 more
doaj   +1 more source

Karyotyping and Distribution Patterns of Endemic Chinese Lilies: Insights Into Their Conservation Under Climate Change

Ecology and Evolution, Volume 16, Issue 1, January 2026.
This study integrates cytogenetic and ecological analyses of two endemic Chinese alpine lilies, Lilium lophophorum (2n = 24) and L. nanum (2n = 48), to establish a foundational understanding of their chromosomal diversity and distribution patterns. We document substantial intraspecific karyotypic variation in diploid L.
Tengfei Gui, Mingyue Lin, Zhiming Li, Deli Peng, Yuan Huang, Wenguang Sun   +5 more
wiley   +1 more source

ATRX: From Chromatin Remodeling to Disease

genesis, Volume 63, Issue 6, December 2025.
ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Mauro Magaña‐Acosta, Viviana Valadez‐Graham   +1 more
wiley   +1 more source

Establishment and Characterization of Bovine Trophoblast Stem Cells Growing as Adherent Cells or Vesicles

Molecular Reproduction and Development, Volume 92, Issue 12, December 2025.
ABSTRACT In ungulates, the development of the trophoblast lineage follows a peculiar process, as implantation is preceded by a relatively long period of trophoblast elongation, the molecular control of which is still not well known. Here, we have established novel bovine trophoblast stem cells (b2iTSCs) growing in a completely defined medium containing
Camille Baquerre, Apolline Delahaye, Vincent Brochard, Fabienne Nuttinck, Christian Jean, Estelle Robert, Clémence Kress, Sylvie Rival‐Gervier, Bertrand Pain, Alice Jouneau   +9 more
wiley   +1 more source

L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline.

PLoS Genetics
Germ cell differentiation in the male testis involves extensive phenotypic, transcriptional, and epigenetic modifications, which are essential for producing functional spermatozoa.
Nina Mayorek, Miriam Schlossberg, Yousef Mansour, Nir Pillar, Ilan Stein, Fatima Mushasha, Guy Baziza Paz, Eleonora Medvedev, Zakhariya Manevitch, Julia Menzel, Elina Aizenshtein, Boris Sarvin, Nikita Sarvin, Erwin Goldberg, Bryan A Niedenberger, Christopher B Geyer, Tomer Shlomi, Michael Klutstein, Eli Pikarsky   +18 more
doaj   +1 more source

Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
The K296E rhodopsin mutation causes autosomal dominant retinitis pigmentosa. The pathogenic effect of the mutation has typically been attributed to effects related to the constitutive activity detected in the mutant in some studies. We demonstrate here that the K296E rhodopsin mutant aggregates.
Sreelakshmi Vasudevan, Vivek Prakash, Paul S.‐H. Park   +2 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants

Advanced Science, Volume 12, Issue 7, February 17, 2025.
A collection of Hi‐C matrices across the plant kingdom confirms the interrelation between large‐scale chromosome conformation and species genome size. At a finer level, tandem duplicate gene clusters preferentially fold into topologically associating domains (TADs) in an evolutionarily conserved manner.
Ni Ma, Xiaopeng Li, Dong Ci, Hai Yue Zeng, Congxiao Zhang, Xiaodong Xie, Caihong Zhong, Xing Wang Deng, Dawei Li, Hang He   +9 more
wiley   +1 more source

SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

eLife
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown.
Ruben Sebastian-Perez, Shoma Nakagawa, Xiaochuan Tu, Sergi Aranda, Martina Pesaresi, Pablo Aurelio Gomez-Garcia, Marc Alcoverro-Bertran, Jose Luis Gomez-Vazquez, Davide Carnevali, Eva Borràs, Eduard Sabidó, Laura Martin, Malka Nissim-Rafinia, Eran Meshorer, Maria Victoria Neguembor, Luciano Di Croce, Maria Pia Cosma   +16 more
doaj   +1 more source

Characterization of radiations‐induced genomic structural variations in Arabidopsis thaliana

The Plant Journal, Volume 121, Issue 1, January 2025.
Significance Statement Exposure to genotoxic stress activates DNA damage response (DDR) and challenges genome integrity. Using third generation sequencing technology, we characterized alterations of the linear genome structure of Arabidopsis plants treated with non‐ionizing (UV‐B, UV‐C) and ionizing radiations (protons). We identified, in wild type and
Salimata Ousmane Sall, Abdelmalek Alioua, Sébastien Staerck, Stéfanie Graindorge, Michel Pellicioli, Jacky Schuler, Catherine Galindo, Quentin Raffy, Marc Rousseau, Jean Molinier   +9 more
wiley   +1 more source