Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction [PDF]
NucleusAberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Andrew D Stephens
exaly +7 more sources
EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis [PDF]
Advanced ScienceEukaryotic translation initiation factor 5A (eIF5A) facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood.
Yuling Cai +15 more
doaj +4 more sources
A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation
Nucleic Acids Research, 2020 During interphase centromeres often coalesce into a small number of chromocenters, which can be visualized as distinct, DAPI dense nuclear domains.
Andreas Schmidt +2 more
exaly +6 more sources
PLoS Genetics, 2021 Pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions, plays crucial roles in various cellular events, such as cell division and DNA replication.
Yota hagihara, Shinpei Yamaguchi
exaly +3 more sources
Cytologia, 2021 Summary Panstrongylus megistus (Burmeister) and Triatoma infestans (Klug), blood-sucking hemipterans in the Reduviidae family, are vectors of Chagas disease.
Maria Luiza S Mello
exaly +3 more sources
The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background [PDF]
Developmental Biology, 2011 Mice homozygous for a mutation (BrdtΔBD1/ΔBD1) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during ...
Debra J Wolgemuth
exaly +3 more sources
Tet1-dependent chromocenter clustering in DNA hypomethylated cells [PDF]
Institutional Repositories DataBase (IRDB), 2021 Hagihara Y, Asada S, Maeda T, Nakano T, Yamaguchi S (2021) Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells. PLoS Genet 17(6): e1009646.
遥太 萩原
semanticscholar +3 more sources
A Strand-Specific Burst in Transcription of Pericentric Satellites Is Required for Chromocenter Formation and Early Mouse Development [PDF]
Developmental Cell, 2010 SummaryAt the time of fertilization, the paternal genome lacks the typical configuration and marks characteristic of pericentric heterochromatin. It is thus essential to understand the dynamics of this region during early development, its importance ...
Geneviève Almouzni +2 more
exaly +3 more sources
Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes [PDF]
Communications Biology, 2023 The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like effectors, RNA-seq and superresolution analysis to determine the effects of genotoxic stress on oocyte ...
Claudia Baumann +9 more
doaj +2 more sources
Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells [PDF]
ACS Chemical Biology, 2021 Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated ‘reader’ proteins.
Nora Guidotti +4 more
semanticscholar +6 more sources