Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes
Communications Biology, 2023 The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like effectors, RNA-seq and superresolution analysis to determine the effects of genotoxic stress on oocyte ...
Claudia Baumann +9 more
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Principles and functions of pericentromeric satellite DNA clustering into chromocenters
Seminars in Cell & Developmental Biology, 2022 Seminars in Cell & Developmental Biology ...
Brändle, Franziska +2 more
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A conserved function for pericentromeric satellite DNA
eLife, 2018 A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown.
Madhav Jagannathan +2 more
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Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila [PDF]
Molecular Biology and Evolution, 2021 Abstract Although rapid evolution of pericentromeric satellite DNA repeats is theorized to promote hybrid incompatibility (HI) (Yunis and Yasmineh 1971; Henikoff et al. 2001; Ferree and Barbash 2009; Sawamura 2012; Jagannathan and Yamashita 2017), how divergent repeats affect hybrid cells remains poorly understood.
Madhav Jagannathan, Yukiko M. Yamashita
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G3: Genes, Genomes, Genetics, 2017 Microscopically visible chromatin is partitioned into two major components in Arabidopsis thaliana nuclei. On one hand, chromocenters are conspicuous foci of highly condensed “heterochromatic” domains that contain mostly repeated sequences.
Basten L. Snoek +8 more
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eLife, 2018 Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.
Susan A Gerbi
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NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects
BMC Bioinformatics, 2022 Background The three-dimensional nuclear arrangement of chromatin impacts many cellular processes operating at the DNA level in animal and plant systems.
Tristan Dubos +8 more
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High-resolution mapping of h1 linker histone variants in embryonic stem cells. [PDF]
PLoS Genetics, 2013 H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that ...
Kaixiang Cao +15 more
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HAC stability in murine cells is influenced by nuclear localization and chromatin organization
BMC Cell Biology, 2009 Background Human artificial chromosomes (HAC) are small functional extrachromosomal elements, which segregate correctly during each cell division. In human cells, they are mitotically stable, however when the HAC are transferred to murine cells they show
Volpi Emanuela V +4 more
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Tissue-specific differences in the spatial interposition of X-chromosome and 3R chromosome regions in the malaria mosquito Anopheles messeae Fall. [PDF]
PLoS ONE, 2015 Spatial organization of a chromosome in a nucleus is very important in biology but many aspects of it are still generally unresolved. We focused on tissue-specific features of chromosome architecture in closely related malaria mosquitoes, which have ...
Gleb Artemov +3 more
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