Results 171 to 180 of about 115,107 (353)

Cholesterol, saturated fats and trans fats

, 2023
Roger Darioli, Pascal Bovet, Nick Banatvala, Kay-Tee Khaw   +3 more
openaire   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Real‐Time High‐Definition Hyperspectral Endoscopy via Spatial‐Temporal Low‐Frequency‐Stochastic Spectral Encoding

Advanced Science, EarlyView.
A real‐time, high‐definition hyperspectral endoscopy is enabled by developing a spatial‐temporal spectral encoding approach based on low‐frequency stochastic filters combined with an encoding‐guided attention network. It provides hyperspectral image of in vivo tissue with fine superficial features, enables visualization of rapid and subtle ...
Xiaowei Liu, Jiakang Shao, Julin Xiao, Chenying Yang, Jiahe Zhang, Xiaoyu Yang, Xiang Hao, Ying Gu, Xu Liu, Yizhou Tan, Ji Qi, Qing Yang   +11 more
wiley   +1 more source

Effects of daily timing of saturated fat and liquid sugar intake on energy balance [PDF]

, 2016
Johanneke E. Oosterman, Laura L. Koekkoek, Ewout Foppen, Eric Fliers, Susanne E. la Fleur, Andries Kalsbeek   +5 more
openalex   +1 more source

Effects of dietary saturated fatty acids on serum high density lipoprotein, non-high-density lipoprotein and remnant-cholesterol in the Reading Imperial Surrey Saturated fat Cholesterol Intervention (RISSCI-1) study [PDF]

, 2021
H. Ayyad, A. Koutsos, Rona Antoni, Gina Wong, Laury Sellem, E. Ozen, Kim G. Jackson, M. Denise Robertson, Barbara A. Fielding, Julie A. Lovegrove, Bruce A. Griffin   +10 more
openalex   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Water‐saturated three‐dimensional balanced steady‐state free precession for fast abdominal fat quantification [PDF]

, 2005
Qi Peng, Roderick McColl, Jihong Wang, Jonathan M. Chia, Paul T. Weatherall   +4 more
openalex   +1 more source

Saturated Fat Avoidance

Science, 1987
openaire   +4 more sources

Nutrition, Fats, Saturated [PDF]

, 2020
openaire   +1 more source