Results 41 to 50 of about 386,637 (303)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Temperature Response Curve of Silicon Diode Temperature Sensors
East European Journal of PhysicsIn this paper the results of the development of a semi-analytical model of the temperature response curve of silicon temperature diode sensors for the case of an arbitrary current transport mechanism, and a physical model that allows for high-precision ...
Damir B. Istamov +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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EnergiesAn algorithm has been implemented and it is provided in this article as an executable program to extract the five solar cell parameters within the one-diode solar cell model.
Victor-Tapio Rangel-Kuoppa
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Modeling and Simulation of a Planar Permanent Magnet On-Chip Power Inductor
ModellingThe on-chip integration of a power inductor together with other power converter components of small sizes and high-saturation currents, while maintaining a desired or high inductance value, is here pursued.
Jaber A. Abu Qahouq +1 more
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Performance Problems of Non-Toroidal Shaped Current Transformers
Sensors, 2020 Nowadays, non-toroidal shape primary pass-through current transformers are commonly used for large current machines with several cables per phase. As these transformers exhibit no radial symmetry, it is not clear if they can be tested using the indirect ...
Carlos A. Platero +4 more
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Prevention of the current transformer saturation by using negative resistance
IET Generation, Transmission & Distribution, 2021 In the power grid, various conditions may occur that saturate the core of a current transformer. Saturation of the protection core of the current transformers can cause a malfunction in the protection relays.
Saeed Sanati, Yousef Alinejad‐Beromi
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Transformer virtual phase protection based on longitudinal impedance
Xi'an Gongcheng Daxue xuebao, 2023 Aimed at the problem that the high harmonics generated by high frequency components in wind power system will affect the operation of substation main transformer protection, a method of transformer longitudinal impedance virtual phase protection is ...
XIA Jingde +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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