Results 161 to 170 of about 2,784 (221)

Bacterial community diversity and potential eco-physiological roles in toxigenic blooms composed of <i>Microcystis</i>, <i>Aphanizomenon</i> or <i>Planktothrix</i>. [PDF]

open access: yesFront Microbiol
Mankiewicz-Boczek J   +11 more
europepmc   +1 more source

Saxitoxin

Angewandte Chemie, 2014
AbstractDie lähmend wirkende Verbindung (+)‐Saxitoxin (STX), die mit den Roten Tiden der Meere und der paralytischen Schalentiervergiftung assoziiert wird, ist ein potenter Inhibitor der elektrischen Leitung in erregbaren Zellen. Seine tückischen Wirkungen sind eine Folge der Hemmung spannungsgesteuerter Natriumionenkanäle (NaVs), d. h.
Arun P, Thottumkara   +2 more
openaire   +3 more sources

A Synthesis of (+)-Saxitoxin

Journal of the American Chemical Society, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
James J, Fleming, J, Du Bois
openaire   +2 more sources

Saxitoxin

Cornea, 2001
The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK).Twelve Dutch belted rabbits were given a single 1.2-microg dose of saxitoxin or vehicle after mechanical abrasion of the cornea.
K G, Duncan, J L, Duncan, D M, Schwartz
openaire   +2 more sources

Neutralization of saxitoxin by anti-saxitoxin rabbit serum

Toxicon, 1985
This study examined the ability of anti-saxitoxin rabbit serum to neutralize saxitoxin, both in vitro and in vivo. In vitro, two rabbit antisera decreased [3H]-saxitoxin binding to specific sites in rat brain membranes. The more potent of these sera, antiserum A, when combined with saxitoxin in vitro, decreased saxitoxin's lethal potency based on mouse
openaire   +2 more sources

The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin

Toxicon, 1995
The potencies of synthetic saxitoxin (+/- STX) and six of its synthetic analogues, including the enantioselectively synthesized unnatural (-)enantiomer of decarbamoyl saxitoxin (dcSTX), were measured and compared to those of natural saxitoxin [(+)STX]. The analogues, all of which were racemic (+/-) mixtures except for dcSTX, varied in the substituents ...
G R, Strichartz   +5 more
openaire   +2 more sources

The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier

Pfl�gers Archiv European Journal of Physiology, 1975
Voltage clamp experiments were done on single nodes of Ranvier of Rana esculenta. Equilibrium effects were obtained from INa-V curves, the rates of action from changes in INa on changing solutions during repetitive depolarizing pulses. 2. Saxitoxin (STX) exclusively and reversibly blocked Na channels, the effect being fully described by a one-to-one ...
H H, Wagner, W, Ulbricht
openaire   +2 more sources

Synthesis of saxitoxins

Pure and Applied Chemistry, 2012
Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)-decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
Osamu Iwamoto   +2 more
openaire   +1 more source

Home - About - Disclaimer - Privacy