Results 151 to 160 of about 1,542 (206)
A rapid bioassay for detecting saxitoxins using a Daphnia acute toxicity test
Environmental Pollution, 2010 Bioassays using Daphnia pulex and Moina micrura were designed to detect cyanobacterial neurotoxins in raw water samples. Phytoplankton and cyanotoxins from seston were analyzed during 15 months in a eutrophic reservoir. Effective time to immobilize 50%
Sandra Azevedo +1 more
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Angewandte Chemie, 2014
AbstractDie lähmend wirkende Verbindung (+)‐Saxitoxin (STX), die mit den Roten Tiden der Meere und der paralytischen Schalentiervergiftung assoziiert wird, ist ein potenter Inhibitor der elektrischen Leitung in erregbaren Zellen. Seine tückischen Wirkungen sind eine Folge der Hemmung spannungsgesteuerter Natriumionenkanäle (NaVs), d. h.
Arun P, Thottumkara +2 more
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AbstractDie lähmend wirkende Verbindung (+)‐Saxitoxin (STX), die mit den Roten Tiden der Meere und der paralytischen Schalentiervergiftung assoziiert wird, ist ein potenter Inhibitor der elektrischen Leitung in erregbaren Zellen. Seine tückischen Wirkungen sind eine Folge der Hemmung spannungsgesteuerter Natriumionenkanäle (NaVs), d. h.
Arun P, Thottumkara +2 more
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Journal of the American Chemical Society, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
James J, Fleming, J, Du Bois
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
James J, Fleming, J, Du Bois
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Photochemical Degradation of Saxitoxins in Surface Waters
ACS ES&T WaterPhotochemical degradation has been shown to be a significant pathway in the environmental fate of many cyanotoxins, compounds produced by harmful cyanobacteria. However, there has been a lack of research on the photochemical fate of saxitoxins.
Frank Leresche +2 more
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Cornea, 2001
The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK).Twelve Dutch belted rabbits were given a single 1.2-microg dose of saxitoxin or vehicle after mechanical abrasion of the cornea.
K G, Duncan, J L, Duncan, D M, Schwartz
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The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK).Twelve Dutch belted rabbits were given a single 1.2-microg dose of saxitoxin or vehicle after mechanical abrasion of the cornea.
K G, Duncan, J L, Duncan, D M, Schwartz
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Regional differences in intra-body distribution of saxitoxins in freshwater pufferfish Pao sp. A from Cambodia [PDF]
ToxiconThe Mekong River in Cambodia is inhabited by approximately ten species of freshwater pufferfish of the family Tetraodontidae. However, limited information is available regarding the toxin profile of these fish.
Yuzuru Utsunomiya +2 more
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Neutralization of saxitoxin by anti-saxitoxin rabbit serum
Toxicon, 1985This study examined the ability of anti-saxitoxin rabbit serum to neutralize saxitoxin, both in vitro and in vivo. In vitro, two rabbit antisera decreased [3H]-saxitoxin binding to specific sites in rat brain membranes. The more potent of these sera, antiserum A, when combined with saxitoxin in vitro, decreased saxitoxin's lethal potency based on mouse
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Toxicon, 1995
The potencies of synthetic saxitoxin (+/- STX) and six of its synthetic analogues, including the enantioselectively synthesized unnatural (-)enantiomer of decarbamoyl saxitoxin (dcSTX), were measured and compared to those of natural saxitoxin [(+)STX]. The analogues, all of which were racemic (+/-) mixtures except for dcSTX, varied in the substituents ...
G R, Strichartz +5 more
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The potencies of synthetic saxitoxin (+/- STX) and six of its synthetic analogues, including the enantioselectively synthesized unnatural (-)enantiomer of decarbamoyl saxitoxin (dcSTX), were measured and compared to those of natural saxitoxin [(+)STX]. The analogues, all of which were racemic (+/-) mixtures except for dcSTX, varied in the substituents ...
G R, Strichartz +5 more
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The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier
Pfl�gers Archiv European Journal of Physiology, 1975Voltage clamp experiments were done on single nodes of Ranvier of Rana esculenta. Equilibrium effects were obtained from INa-V curves, the rates of action from changes in INa on changing solutions during repetitive depolarizing pulses. 2. Saxitoxin (STX) exclusively and reversibly blocked Na channels, the effect being fully described by a one-to-one ...
H H, Wagner, W, Ulbricht
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Bioorganic Chemistry, 1981
Abstract The preparation, spectral characterization, chromatographic and biological properties of several derivatives of saxitoxin, a highly potent neurotoxin, are described. Derivatives include decarbamoylsaxitoxin, both epimers of dihydrosaxitoxin (α- and β-saxitoxinol) and both epimers of decarbamoylsaxitoxinol, as well as several isotopically ...
Frank E. Koehn +4 more
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Abstract The preparation, spectral characterization, chromatographic and biological properties of several derivatives of saxitoxin, a highly potent neurotoxin, are described. Derivatives include decarbamoylsaxitoxin, both epimers of dihydrosaxitoxin (α- and β-saxitoxinol) and both epimers of decarbamoylsaxitoxinol, as well as several isotopically ...
Frank E. Koehn +4 more
openaire +1 more source