Results 41 to 50 of about 723,869 (275)

W(h)ither Fossils? Studying Morphological Character Evolution in the Age of Molecular Sequences [PDF]

, 2008
A major challenge in the post-genomics era will be to integrate molecular sequence data from extant organisms with morphological data from fossil and extant taxa into a single, coherent picture of phylogenetic relationships; only then will these ...
Bull J. J., Cuevas J., Desutter-Grandcolas L., Eernisse D. J., Elizabeth J. Hermsen, Giribet G., Grande L., Hedges S. B., Hermsen E. J., Horovitz I., Horovitz I., Jonathan R. Hendricks, Luckow M., Montgelard C., Norell M. A., Novacek M. J., O'Leary M., Rowe T., Simmons N. B., Wiens J. J., Xiang Q-Y. J., Zhang J.   +21 more
core   +2 more sources

Hyaluronic acid-recombinant gelatin gels as a scaffold for soft tissue regeneration [PDF]

European Cells & Materials, 2012
An array of different types of hyaluronic acid (HA)- and collagen-based products is available for filling soft-tissue defects. A major drawback of the current soft-tissue fillers is their inability to induce cell infiltration and new tissue formation ...
A Tuin, J Zandstra, SG Kluijtmans, JB Bouwstra, MC Harmsen, MJA Van Luyn   +5 more
doaj  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review

Journal of Functional Biomaterials
The use of blood plasma, fibrinogen or fibrin, a natural biomaterial, has been widely studied for the development of different skin tissue-engineered products and other dermatological treatments.
Álvaro Sierra-Sánchez, Raquel Sanabria-de la Torre, Ana Ubago-Rodríguez, María I. Quiñones-Vico, Trinidad Montero-Vílchez, Manuel Sánchez-Díaz, Salvador Arias-Santiago   +6 more
doaj   +1 more source

Meniscus repair and regeneration: review on current methods and research potential [PDF]

European Cells & Materials, 2013
Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage ...
C Scotti, MT Hirschmann, P Antinolfi, I Martin, GM Peretti   +4 more
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effectiveness of 2D fingerprints for scaffold hopping

, 2011
Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J., Holliday, J.D., O'Dowd, C., Willett, P.   +3 more
core   +1 more source

PVA Hydrogels Supplemented with PLA Mesh for Tissue Regeneration Scaffold

Gels
This study examined the tensile strength and biocompatibility properties of polyvinyl alcohol (PVA) hydrogel tissue regeneration scaffolds with polylactic acid (PLA) mesh fabric added as reinforcement, with a focus on the impact of heat treatment ...
Young-Ho Seo, Jae-Man Lee, Sun-Young Park, Myung-Hoo Kim, Seon-Beom Kim, Tae-Hwan Oh   +5 more
doaj   +1 more source

Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model [PDF]

European Cells & Materials, 2012
Peripheral artery disease (PAD) currently affects approximately 27 million patients in Europe and North America, and if untreated, may progress to the stage of critical limb ischemia (CLI), which has implications for amputation and potential mortality ...
JA DeQuach, JE Lin, C Cam, D Hu, MA Salvatore, F Sheikh, KL Christman   +6 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source