Scaffold-Induced Molecular Graph (SIMG): Effective Graph Sampling Methods for High-Throughput Computational Drug Discovery [PDF]
arXiv, 2021 Scaffold based drug discovery (SBDD) is a technique for drug discovery which pins chemical scaffolds as the framework of design. Scaffolds, or molecular frameworks, organize the design of compounds into local neighborhoods. We formalize scaffold based drug discovery into a network design. Utilizing docking data from SARS-CoV-2 virtual screening studies
arxiv
Understanding the Effects of Using Parsons Problems to Scaffold Code Writing for Students with Varying CS Self-Efficacy Levels [PDF]
, 2023 Introductory programming courses aim to teach students to write code independently. However, transitioning from studying worked examples to generating their own code is often difficult and frustrating for students, especially those with lower CS self-efficacy in general.
arxiv +1 more source
Strategies, methods and tools for managing nanorisks in construction [PDF]
, 2015 This paper presents a general overview of the work carried out by European project SCAFFOLD (GA 280535) during its 30 months of life, with special emphasis on risk management component.
A Pintea +50 more
core +2 more sources
Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives
Polymers, 2016 Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to ...
Chanjuan Dong, Y. Lv
semanticscholar +1 more source
, 2018 The goal of this paper is to construct a quadrilateral mesh around a one-dimensional skeleton that is as coarse as possible, the " scaffold ". A skeleton allows one to quickly describe a shape, in particular a complex shape of high genus. The constructed scaffold is then a potential support for the surface representation: it provides a topology for the
Panotopoulou, Athina +4 more
openaire +5 more sources
3D Graphene Scaffolds for Skeletal Muscle Regeneration: Future Perspectives
Frontiers in Bioengineering and Biotechnology, 2020 Although skeletal muscle can regenerate after injury, in chronic damages or in traumatic injuries its endogenous self-regeneration is impaired.
Valentina Palmieri +7 more
doaj +1 more source
Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem [PDF]
arXiv, 2022 Construction of a scaffold structure that supports a desired motif, conferring protein function, shows promise for the design of vaccines and enzymes. But a general solution to this motif-scaffolding problem remains open. Current machine-learning techniques for scaffold design are either limited to unrealistically small scaffolds (up to length 20) or ...
arxiv
Development of a Computational Model for Cell Activity in a Nano-Scaffold [PDF]
, 2020 Tissue engineering utilizes nano-scaffolds to direct cell growth and control cell behavior. Since cells occupy specific spaces within extracellular matrix (ECM) it’s important to understand how the geometry of these spaces influence cell behaviors such ...
Babcock, Ethan, Luke, Bethany
core +1 more source
Decellularized diaphragmatic muscle drives a constructive angiogenic response in vivo [PDF]
, 2018 Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and acquired defects. Biological acellular scaffolds are considered a good tool for TE, as decellularization allows structural preservation of tissue extracellular matrix
Alvar\ue8z Fallas, Mario +11 more
core +3 more sources
A polymer scaffold for self-healing perovskite solar cells
Nature Communications, 2016 Advancing of the lead halide perovskite solar cells towards photovoltaic market demands large-scale devices of high-power conversion efficiency, high reproducibility and stability via low-cost fabrication technology, and in particular resistance to humid
Yicheng Zhao +6 more
semanticscholar +1 more source