Results 91 to 100 of about 160,812 (310)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Children's performance on and understanding of the balance scale problem: the effects of adult support

, 2007
The present thesis investigated the Vygotskian notion that social influences are necessary for children's learning to take place, and that the process of conceptual development via Representational Redescription, described by Karmiloff-Smith (1992 ...
Philips, Sharon
core   +1 more source

Effects of adaptive scaffolding on performance, cognitive load and engagement in game-based learning: a randomized controlled trial

BMC Medical Education
Background While game-based learning has demonstrated positive outcomes for some learners, its efficacy remains variable. Adaptive scaffolding may improve performance and self-regulation during training by optimizing cognitive load. Informed by cognitive
Tjitske J. E. Faber, Mary E. W. Dankbaar, Walter W. van den Broek, Laura J. Bruinink, Marije Hogeveen, Jeroen J. G. van Merriënboer   +5 more
doaj   +1 more source

PENGEMBANGAN MODUL AJAR SCAFFOLDING METAKOGNITIF BERBASIS LITERASI MATEMATIS UNTUK SISWA SMA

Aksioma: Jurnal Program Studi Pendidikan Matematika
Siswa diharapkan memiliki kemampuan literasi matematis, yang berkorelasi dengan kompetensi matematis, karena keduanya akan meningkatkan kualitas hidup mereka.
Nita Hidayati, Ramlah Ramlah, Hanifah Hanifah, Adiesty Novia Yesiliana, Siti Annisa Samsudin   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Green Scaffolding

, 2005
Given the resource flows through new construction, eco-retrofitting is an essential prerequisite\ud of sustainability. Exemplars showing how to eco-retrofit cities will facilitate\ud transfer, experimentation and adoption.
Birkeland, Janis
core  

The Influences of Inquiry Learning Model with Scaffolding on Scientific Literacy and Learning Outcomes

The purpose of this study is to analyze the significant effect of the inquiry model with scaffolding on science literacy and science learning outcomes. This type of research uses quasi-experimental and quantitative methods with a non-equivalent posttest ...
Mashfufah, Aynin, Aynin Mashfufah, Supriyono Koeshandayanto, Koeshandayanto, Supriyono, Luluk Nur Hamidah, Hamidah, Luluk Nur   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Somatosensory scaffolding structures [PDF]

Frontiers in Molecular Neuroscience, 2012
Dynamic changes in somatosensory perception occur as a result of multiple signaling events. In many instances, over-activation of sensory receptors results in the desensitization and subsequent increased threshold for activation of receptors. In other cases, receptor sensitization can occur following tissue injury and/or inflammation.
openaire   +3 more sources