Results 111 to 120 of about 160,812 (310)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Analysis of students' dual processes in solving number pattern questions and providing scaffolding

Journal Focus Action of Research Mathematic
This research aims to describe students' dual-process in solving number pattern questions and scaffolding that support students' dual-process. This research uses a qualitative research approach with a case study type.
Ganis Irma Firnanda, Susiswo
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Teacher Scaffolding of Preschoolers' Shared Reading With a Storybook App and a Printed Book

, 2020
Teachers are increasingly using new technologies such as tablets and apps during shared reading experiences at preschool. However, little is known about how teachers scaffold young children’s shared reading with interactive e-books such as tablet-based ...
Neumann, Michelle M
core   +1 more source

Fremde Sprachen lernen durch die Lektüre öffentlicher Räume

Journal of Linguistics and Language Teaching, 2020
Öffentliche Räume bieten ein ideales Gerüst zur Unterstützung beim Erlernen fremder Sprachen (scaffolding), denn hier erscheinen kurze, oft standardisierte und in leichten Variationen häufig wiederholte Texte an Stellen, deren vorstrukturierter ...
Ulrich Schmitz
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Toward an innovation radar for cultivated meat: exploring process technologies for cultivated meat and claims about their social impacts

Frontiers in Sustainable Food Systems
IntroductionCultivated meat has received growing attention since claims were made that cultivated meat can be produced more ethically and sustainably than the current meat production.
Lisa Woelken, Dagmara M. Weckowska, Carsten Dreher, Cornelia Rauh   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

‘It’s easy!’: scaffolding literacy for teaching multimodal texts

, 2016
This article proposes a modification of Axford, Harders and Wise’s (2009) Scaffolding Literacy sequence to support the creation of multimodal persuasive texts by students in Year 5.
Lowien, Nathan
core