Results 121 to 130 of about 160,812 (310)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Scaffolding librarians: enhancing student success

This presentation details a successful change in learning and teaching practice by the librarians at the University of Northampton, following the findings of an action research project involving the Early Childhood Studies undergraduate course.
McBryde-Wilding, Heather, Rose, Hannah
core  

Looking in: Mapping representations of teachers' discursive writing practices

, 2014
Over the past four decades changes in political, social, and educational curriculum policies have created discursive shifts in writing theory and practice.
Dix, Stephanie Margaret
core  

Exploring Student Perspectives and Practices with Language-Aware Materials in Geography Education: An Exploratory Case Study in a German High School Classroom

European Journal of Geography
Developing language-aware teaching materials is increasingly recognized as essential for enhancing both language proficiency and content acquisition in diverse classroom settings.
Michael Morawski, Panagiota Georgakaki
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Theatrical dramatization between scaffolding and cooperative learning, in history education. A case study in a fifth-grade primary classroom

reservedIl presente studio di caso si è proposto di analizzare l’efficacia della drammatizzazione teatrale, integrata con strategie di scaffolding e Cooperative Learning, come strumento didattico e pedagogico per l’insegnamento della storia in una ...
PAGLIAROTO, RENZO GIOVANNI
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Mechanism of Scaffolding-Directed Virus Assembly Suggested by Comparison of Scaffolding-Containing and Scaffolding-Lacking P22 Procapsids

, 1999
Assembly of certain classes of bacterial and animal viruses requires the transient presence of molecules known as scaffolding proteins, which are essential for the assembly of the precursor procapsid.
Thuman-Commike, Pamela A., Greene, Barrie, Malinski, Justine A., McGough, Amy, Chiu, Wah, Prevelige, Peter E., Burbea, Michelle   +6 more
core   +1 more source

A scaffolded training series to develop Clinical and Translational Researchers in Hawai‘i

Journal of Clinical and Translational Science
We describe a training series using a scaffolded approach informed by Vygotsky’s Learning Theory to advance Hawai‘i -based faculty grant-writing skills. Sponsored by the Professional Development Core of the Center for Pacific Innovations, Knowledge, and ...
Merle Kataoka-Yahiro, F. David Horgen, Dedra Buchwald, Claire Townsend Ing, Spero M. Manson, Joseph Keawe‘aimoku Kaholokula, Kathryn L. Braun   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source