Results 111 to 120 of about 373,160 (277)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Étayage en ligne et développement de la conscience métacognitive

ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2019
The following article describes a case study based on a telecollaboration between two groups of learners studying French as a second/foreign language. Supported by Activity Theory and the notion of scaffolding, we seek to analyse whether collaborative ...
Catherine Caws, Eliane Lousada, Arthur Marra   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Analysis of students' dual processes in solving number pattern questions and providing scaffolding

Journal Focus Action of Research Mathematic
This research aims to describe students' dual-process in solving number pattern questions and scaffolding that support students' dual-process. This research uses a qualitative research approach with a case study type.
Ganis Irma Firnanda, Susiswo
doaj   +1 more source

The legal and technical possibilities of using of scaffoldings as the ramp for disabled persons

Budownictwo i Architektura, 2015
The paper is devoted to the problems of legal and technical making the ramp for disabled persons with scaffolds. Scaffolding system components allow you to assemble a structure that serve as the ramp and fulfil the requirements of technical conditions ...
Ewa Błazik-Borowa, Michał Pieńko, Aleksander Robak   +2 more
doaj   +1 more source

Scaffolding Cognition with Words [PDF]

, 2005
We describe a set of experiments investigating the role of natural language symbols in scaffolding situated action. Agents are evolved to respond appropriately to commands in order to perform simple tasks.
Clowes, Robert, Morse, Anthony F.
core  

Reduction for $SL(3)$ pre-buildings

, 2016
Given an $SL(3)$ spectral curve over a simply connected Riemann surface, we describe in detail the reduction steps necessary to construct the core of a pre-building with versal harmonic map whose differential is given by the spectral ...
Katzarkov, Ludmil, Pandit, Pranav, Simpson, Carlos   +2 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Fremde Sprachen lernen durch die Lektüre öffentlicher Räume

Journal of Linguistics and Language Teaching, 2020
Öffentliche Räume bieten ein ideales Gerüst zur Unterstützung beim Erlernen fremder Sprachen (scaffolding), denn hier erscheinen kurze, oft standardisierte und in leichten Variationen häufig wiederholte Texte an Stellen, deren vorstrukturierter ...
Ulrich Schmitz
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source