Results 91 to 100 of about 9,449,404 (314)
Cosmological Constraints on Bose-Einstein-Condensed Scalar Field Dark Matter [PDF]
, 2013 Despite the great successes of the cold dark matter (CDM) model in explaining a wide range of observations of the global evolution and the formation of galaxies and large-scale structure in the Universe, the origin and microscopic nature of dark matter ...
Bohua Li, T. Rindler-Daller, P. Shapiro
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
From massless free scalar field to conformal field theories [PDF]
, 2023 Yitzhak Frishman, Jacob Sonnenschein
openalex +1 more source
Past-directed scalar field gradients and scalar-tensor thermodynamics. [PDF]
Gen Relativ Gravit, 2023 Giusti A, Giardino S, Faraoni V.
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Cosmological Dynamics of Anisotropic Kaniadakis Holographic Dark Energy Model in Brans-Dicke Gravity
East European Journal of PhysicsThe present study examines the Kaniadakis holographic dark energy in the context of the Brans-Dicke scalar-tensor theory of gravity (Phys. Rev. 124: 925, 1961).
A. Vijaya Prasanthi +3 more
doaj +1 more source
Scalar field as a perfect fluid: thermodynamics of minimally coupled scalars and Einstein frame scalar-tensor gravity. [PDF]
Eur Phys J C Part Fields, 2023 Faraoni V +3 more
europepmc +1 more source