Results 61 to 70 of about 3,374,770 (347)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Sequential Probabilistic Ratio Test for the Scale Parameter of the P-Norm Distribution
Discrete Dynamics in Nature and Society, 2021 We consider a series of independent observations from a P-norm distribution with the position parameter μ and the scale parameter σ. We test the simple hypothesis H0:σ=σ1 versus H1: σ=σ2.
Huan Ren, Hongchang Hu, Zhen Zeng
doaj +1 more source
, 2006 We argue that given the experimental constraints on the Higgs mass the least fine tuned parameter space of minimal supersymmetric standard model is with negative stop masses squared at the grand unification scale.
Dermisek, Radovan, Kim, Hyung Do
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Renewed empirical formulas for estimating Weibull distribution parameters
Компьютерная оптикаThe empirical formulas proposed in the literature for estimating the parameters of a two-parameter Weibull distribution, obtained using the equations of the moment method, are considered. It is noted that the formulas used to estimate the shape parameter
D.G. Asatryan
doaj +1 more source
, 2008 We report planar tunneling measurements on thin films of YBa$_2$Cu$_3$O$_{7-x}$ at various doping levels under magnetic fields. By choosing a special setup configuration, we have probed a field induced energy scale that dominates in the vicinity of a ...
A. Aubin +9 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Frontiers in Plant ScienceQuantifying inequality in the leaf area distribution within a single module is critical for elucidating plant resource allocation strategies, but the accuracy of theoretical Gini coefficients derived from statistical distributions remains poorly ...
Zhifei Jiao +7 more
doaj +1 more source
Single parameter aging and density scaling
The Journal of Chemical PhysicsIn a recent paper, Di Lisio et al. [J. Chem. Phys. 159, 064505 (2023)] analyzed a series of temperature down-jumps using the single-parameter aging (SPA) ansatz combined with a specific assumption about density scaling in the out-of-equilibrium system and did not find a good prediction for the largest down-jumps.
Tina Hecksher, Kristine Niss
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source