Results 71 to 80 of about 8,394 (182)

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

COMPARISON OF THE EFFECTIVENESS OF FORMALIZED SCORING SYSTEMS IN PREDICTING OUTCOMES IN PATIENTS WITH SEVERE COMMUNITY-ACQUIRED PNEUMONIA OF BACTERIAL AND VIRAL ETIOLOGY

Паёми Сино
Objective: To compare outcome prediction scales and stratify risk groups high short-term mortality of patients with sCAP of viral and bacterial etiology.
Ruslyakova Irina Anatolyevna, Shamsutdinova Elvina Zinurovna, Mironova Yulia Aleksandrovna, Chertsov Ilya Sergeevich,, Shirokov Kirill Igorevich, Avalueva Elena Borisovna   +5 more
doaj   +1 more source

Stem cells from tooth apical papilla modulate fibromyalgia-like changes in mice

Brain Research Bulletin
Background: The treatment of fibromyalgia remains a current challenge. While the analgesic effects of mesenchymal stem cells have been the subject of previous research, their potential in managing fibromyalgia symptoms needs further investigation.
Ana P.A. Dagnino, Gabriel Rübensam, Jefferson B. Silva, Maria M. Campos   +3 more
doaj   +1 more source

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.

PLoS Biology, 2013
The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of ...
Ryo Suzuki, Heather A Ferris, Melissa J Chee, Eleftheria Maratos-Flier, C Ronald Kahn   +4 more
doaj   +1 more source

Spatial and Objective Decompositions for Very Large SCAPs [PDF]

, 2011
This paper reconsiders the single commodity allocation problem (SCAP) for disaster recovery, which determines where and how to stockpile a commodity before a disaster and how to route the commodity once the disaster has hit. It shows how to scale the SCAP algorithm proposed in [1] to a geographical area with up to 1,000 storage locations (over a ...
Carleton Coffrin, Pascal Van Hentenryck, Russell Bent   +2 more
openaire   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation

Heliyon
Neuro-inflammation occurs in numerous disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. However, anti-inflammatory drugs for the central nervous system have failed to show significant improvement when compared to a ...
Viridiane Gratpain, Axelle Loriot, Pauline Bottemanne, Ludovic d’Auria, Romano Terrasi, Valéry L. Payen, Vincent van Pesch, Giulio G. Muccioli, Anne des Rieux   +8 more
doaj   +1 more source

Immunomodulatory effects of apical papilla cells on periodontal ligament fibroblasts stimulated with Escherichia coli lipopolysaccharide: an in vitro study [PDF]

Journal of Applied Oral Science
The role of human Stem Cells from the Apical Papilla (SCAP) in tissue regeneration has been described, but their impact on modulating the apical inflammatory process by other surrounding cell populations, such as periodontal ligament fibroblasts (PLFs ...
Alexandre Guimarães dos SANTOS, Karollyne Santos SPIGARIOL, Letícia Martins SANTOS, Marinella HOLZHAUSEN, Carla Renata SIPERT   +4 more
doaj   +1 more source