Results 91 to 100 of about 11,276 (233)

Stem cells from apical papilla-derived exosomes alleviate bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

Materials & Design
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, refractory osteonecrosis caused by prolonged bisphosphonate therapy. Stem cells from apical papilla-derived exosomes (SCAP-Exo), measuring 30–150 nm in diameter, have been shown to ...
Xuesong Zhu, Yu Wang, Mingchen Ma, Xiaoli Li, Si Yu, Yao Liu, Aochen Wang   +6 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Characterization of human SCAP in comparison with DPSCs.

, 2013
(A) Western blot analysis to confirm protein expression of genes identified in microarray studies showed greater abundance of survivin in SCAP than in DPSCs, with similar levels of DSP and Cbfa1/Runx2.
Yi Liu (36759), Dianji Fang (67505), Byoung-Moo Seo (67507), Cun-Yu Wang (34940), Songtao Shi (67511), Wataru Sonoyama (67504), Stan Gronthos (67510), Songlin Wang (67512), Takayoshi Yamaza (67506), Chunmei Zhang (67508), He Liu (67509)   +10 more
core   +1 more source

Immunomodulatory effects of apical papilla cells on periodontal ligament fibroblasts stimulated with Escherichia coli lipopolysaccharide: an in vitro study [PDF]

Journal of Applied Oral Science
The role of human Stem Cells from the Apical Papilla (SCAP) in tissue regeneration has been described, but their impact on modulating the apical inflammatory process by other surrounding cell populations, such as periodontal ligament fibroblasts (PLFs ...
Alexandre Guimarães dos SANTOS, Karollyne Santos SPIGARIOL, Letícia Martins SANTOS, Marinella HOLZHAUSEN, Carla Renata SIPERT   +4 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth [PDF]

, 2020
The placental labyrinth is important for the exchange of nutrients and gases between the mother and the embryo in mice. This interface contains cells of both trophoblast and allantoic mesodermal origin that together produce maternal blood sinuses and ...
Rao, Y, Ruan, XZ, Li, Z, Yao, Y, Wei, L, Hou, X, Zheng, G, Li, D, Liu, M, Chen, Y   +9 more
core   +1 more source

Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap–Insig interaction and SREBP activation

Proceedings of the National Academy of Sciences
Cholesterol homeostasis in mammalian cells relies on the interaction between two endoplasmic reticulum (ER) sterol-sensing membrane proteins, Scap and Insig. Their interaction regulates activation of transcription factors called sterol regulatory element–binding proteins (SREBPs) that control genes for cholesterol biosynthesis and uptake.
Blake C. Williams, Daniel L. Kober, Xiao-chen Bai, Daniel M. Rosenbaum, Arun Radhakrishnan   +4 more
openaire   +3 more sources

Which aspects of restoration project organization relate to volunteer engagement in community‐based initiatives?

Restoration Ecology, EarlyView.
Abstract Introduction Project organization is an under‐studied but important aspect of volunteer engagement in ecological restoration and conservation. Previous studies on volunteer commitment have found that people are more engaged in well‐organized projects, but what constitutes good project organization from a volunteer perspective has not been ...
Tim Alamenciak, Stephen D. Murphy
wiley   +1 more source

Identification of subtypes and construction of a predictive model for novel subtypes in severe community-acquired pneumonia based on clinical metagenomics: a multicenter, retrospective cohort study

Frontiers in Cellular and Infection Microbiology
ObjectiveIt is well recognized that high heterogeneity represents a key driver of the elevated mortality in severe community-acquired pneumonia (sCAP).
Shiyi Chen, Yongpo Jiang, Dongqing Lv, Ye Zheng, Ruihai Zhang, Hanzhi Dai, Ziyi Wang, Shuyang Li, Rongbin Qi, Hailing Xu, Yingying Yu, Cailin Xu, Xuanyu Lu, Yinghe Xu, Shengwei Jin, Xiaomai Wu   +15 more
doaj   +1 more source