Results 81 to 90 of about 2,580 (206)

Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3

Scientific Reports, 2017
Transcription factor GATA4 regulates cardiac and osteoblast differentiation. However, its role in tooth development is not clear. Therefore, we generated Wnt1-Cre;GATA4 fl/fl mice, with conditional inactivation of the GATA4 gene in the dental papilla ...
Shuyu Guo, Yuxin Zhang, Tingting Zhou, Dongyue Wang, Yajuan Weng, Lin Wang, Junqing Ma   +6 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review

Journal of Cutaneous Pathology, Volume 53, Issue 9, Page 772-782, September 2026.
ABSTRACT Malignant transformation is known to occur with many nevi, such as nevus sebaceus. However, cases of secondary tumors developing in an epidermal nevus (EN) are rare, with only a few case reports documented in the literature. We present three unique cases of syringocystadenoma papilliferum (SCAP), syringofibroadenoma, trichilemmoma, and basal ...
Haya A. Homsi, Melissa Piliang, Jennifer Lucas, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

Development of a Nano‐Hybrid Composite Using Bovine Hydroxyapatite and Montmorillonite for Endodontic Applications—An In Vitro Study

International Endodontic Journal, Volume 59, Issue 9, Page 1936-1953, September 2026.
ABSTRACT Aim Hydraulic calcium silicate cements are widely employed in endodontics due to their excellent biocompatibility, bioactivity, sealing ability, and remineralisation potential. However, currently used products such as mineral trioxide aggregate (MTA) exhibit several limitations, including discolouration, cost, and poor handling properties ...
P. A. A. S. Prasad Kumara, Paul R. Cooper, Peter Cathro, Henry F. Duncan, Maree Gould, George Dias, Jithendra Ratnayake   +6 more
wiley   +1 more source

Study on the promotion of osteo/odontogenic differentiation on SCAPs and anti-inflammatory effects of EGCG/CeO2-loaded nanoparticles in an inflammatory microenvironment [PDF]

Kouqiang yixue
Objective To investigate the effects of composite nanoparticles E/Ce@MCSNs loaded with epigallocatechin-3-gallate (EGCG) and cerium dioxide (CeO2) on the odonto/osteogenic differentiation of human stem cells from the apical papilla (SCAPs) and macrophage
WU Yuting, DAI Mingrui, LENG Diya, ZHU Tingting, WU Tao, WU Daming
doaj   +1 more source

Regenerative Endodontics in Teeth With Irreversible Pulpitis: A Scoping Review

International Endodontic Journal, Volume 59, Issue 9, Page 1792-1803, September 2026.
ABSTRACT Introduction Regenerative endodontic procedures (REPs) have been widely used to manage a range of pulpal pathologies, particularly in immature permanent teeth. The development of bioactive calcium silicate–based materials has led to a paradigm shift in vital pulp therapy (VPT) and REPs.
Mahmoud Torabinejad, Neda Najafimakhsoos, George Bogen   +2 more
wiley   +1 more source

3D culture inhibits replicative senescence of SCAPs via UQCRC2-mediated mitochondrial oxidative phosphorylation

Journal of Translational Medicine
Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed cells for bone/tooth tissue engineering.
Yijia Shi, Tong Xiao, Yingying Weng, Ya Xiao, Jintao Wu, Jing Wang, Wenmin Wang, Maoshen Yan, Ming Yan, Zehan Li, Jinhua Yu   +10 more
doaj   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source