Results 11 to 20 of about 2,437,132 (390)

The Role of Scavenger Receptor BI in Sepsis. [PDF]

Int J Mol Sci
Sepsis is a life-threatening condition resulting from a dysregulated host response to infection. Currently, there is no effective therapy for sepsis due to an incomplete understanding of its pathogenesis. Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that plays a key role in HDL metabolism by modulating the selective uptake
Hao D, Xue JY, Wang Q, Guo L, Li XA.
europepmc   +3 more sources

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

PLoS Pathogens, 2018
Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry receptor for human adenoviruses in murine alveolar macrophage-like MPI cells,
Nicole Stichling, Maarit Suomalainen, Justin W Flatt, Markus Schmid, Martin Pacesa, Silvio Hemmi, Wolfgang Jungraithmayr, Mareike D Maler, Marina A Freudenberg, Andreas Plückthun, Tobias May, Mario Köster, György Fejer, Urs F Greber   +13 more
doaj   +2 more sources

Activated scavenger receptor A promotes glial internalization of aβ. [PDF]

PLoS ONE, 2014
Beta-amyloid (Aβ) aggregates have a pivotal role in pathological processing of Alzheimer's disease (AD). The clearance of Aβ monomer or aggregates is a causal strategy for AD treatment.
He Zhang, Ya-jing Su, Wei-wei Zhou, Shao-wei Wang, Peng-xin Xu, Xiao-lin Yu, Rui-tian Liu   +6 more
doaj   +2 more sources

Macrophage Scavenger Receptor Class A [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract—In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes.
Menno P.J. de Winther, Ko Willems van Dijk, Louis M. Havekes, Marten H. Hofker   +3 more
openalex   +5 more sources

Scavenger Receptor C1 Mediates Toxicity of Binary Toxin from Lysinibacillus sphaericus to Ag55 Cells [PDF]

Toxins
Lysinibacillus sphaericus harboring Binary (BinA and BinB) toxins is highly toxic against Anopheles and Culex mosquito larvae. The Anopheles Ag55 cell line is a suitable model for investigating the mode of Bin toxin action.
Qi Zhang, Gang Hua, Laramie Smith, Michael J. Adang   +3 more
doaj   +2 more sources

Scavenger receptors [PDF]

Current Biology, 2020
Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets.
Ali, Alquraini, Joseph, El Khoury
openaire   +2 more sources

Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium

Frontiers in Physiology, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller, Mark T. Fuller, Omid Dadoo, Omid Dadoo, Ting Xiong, Ting Xiong, Pardh Chivukula, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Samuel K. Lee, Richard C. Austin, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti, Bernardo L. Trigatti   +15 more
doaj   +1 more source

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Nature Communications, 2020
Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants.
F. Hu, Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen, Wei Zhang, Yan Du, Ping Wang, Xi Zheng, X. Fang, Xin Li, Jing Song, Yang-yang Xie, F. Huang, J. Xue, M. Bai, Yuan Jia, Xu Liu, L. Ren, Xiaoying Zhang, Jianping Guo, Hu-dan Pan, Yin Su, H. Yi, H. Ye, Daming Zuo, Juan Li, Huaxiang Wu, Yongfu Wang, Ru Li, Liang Liu, Xiang-Yang Wang, Zhanguo Li   +32 more
semanticscholar   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
Dansako, Hiromichi, Hu, Fengyu, Kato, Nobuyuki, Lemon, Stanley M., McGivern, David R., Welsch, Christoph, Yamane, Daisuke   +6 more
core   +11 more sources

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Here we report that targeting the pattern recognition receptor MARCO on macrophages within the tumor alters their polarization and in turn activate natural killer (NK) cells to kill the tumor.
S. Eisinger, D. Sarhan, Vanessa F. Boura, Itziar Ibarlucea-Benitez, Sofia Tyystjärvi, G. Oliynyk, Marie Arsenian-Henriksson, D. Lane, Stina L Wikström, R. Kiessling, Tommaso Virgilio, S. F. Gonzalez, D. Kaczynska, Shigeaki Kanatani, E. Daskalaki, C. Wheelock, S. Sedimbi, B. Chambers, J. Ravetch, M. Karlsson   +19 more
semanticscholar   +1 more source