Results 1 to 10 of about 103,100 (354)

Scavenger receptor class B type I is a plasma membrane cholesterol sensor. [PDF]

Circ Res, 2013
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW.   +14 more
europepmc   +6 more sources

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems [PDF]

Journal of Clinical Investigation, 2001
Scavenger receptors (SRs) are defined as cell surface membrane proteins that bind chemically modified lipoproteins, such as acetylated LDL (AcLDL) and oxidized LDL (OxLDL), and often many other types of ligands (1–3).
Monty Krieger
semanticscholar   +6 more sources

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. [PDF]

PLoS ONE, 2012
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein
Guodong Li, Ann M Thomas, Jessica A Williams, Bo Kong, Jie Liu, Yuka Inaba, Wen Xie, Grace L Guo   +7 more
doaj   +10 more sources

Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine [PDF]

Journal of Lipid Research, 2001
The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai, R. Jason Kirby, Philip N. Howles, David Y. Hui   +3 more
doaj   +5 more sources

Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice [PDF]

Journal of Translational Medicine, 2018
Background Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cholesterol enriched, and functional ...
Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu   +5 more
doaj   +6 more sources

Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. [PDF]

Breast Cancer Res, 2013
IntroductionPrevious studies have identified cholesterol as an important regulator of breast cancer development. High-density lipoprotein (HDL) and its cellular receptor, the scavenger receptor class B type I (SR-BI) have both been implicated in the ...
Danilo C, Gutierrez-Pajares JL, Mainieri MA, Mercier I, Lisanti MP, Frank PG.   +5 more
europepmc   +4 more sources

Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques [PDF]

BMC Cardiovascular Disorders, 2005
Background The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile.
Fagerberg Björn, Thelle Dag S, Mattsson-Hulten Lillemor, Stemme Veronika, Ohlsson Bertil G, Hägg Daniel A, Snäckestrand Magnus SC, Englund Mikael CO, Svensson Per-Arne, Wiklund Olov, Carlsson Lena MS, Carlsson Björn   +11 more
doaj   +7 more sources

Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics [PDF]

Journal of Biological Chemistry, 2000
Both in vitro and in vivostudies of scavenger receptor class B type I (SR-BI) have implicated it as a likely participant in the metabolism of HDL cholesterol.
Yukihiko Ueda, Elaine L. Gong, Lori Royer, Philip Cooper, Omar L. Francone, Edward M. Rubin   +5 more
semanticscholar   +6 more sources

Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner. [PDF]

PLoS ONE
ObjectiveHomozygous knockout of scavenger receptor class B type I (SR-B1) in mice with atherogenic mutations (such as knockout of the apolipoprotein E or low density lipoprotein receptor genes) results in spontaneous or diet-induced coronary heart ...
Samuel K Lee, Ting Xiong, Alexander S Qian, Jeong-Ah Yoo, B Sumayyah H Sokeechand, Mark T Fuller, Peter L Gross, Richard C Austin, Suleiman A Igdoura, Bernardo L Trigatti   +9 more
doaj   +3 more sources

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver. [PDF]

Histochem Cell Biol, 2014
The high-density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediates selective cholesteryl ester uptake into the liver, which finally results in cholesterol secretion into the bile. Despite several reports, the distribution of hepatic SR-BI between the sinusoidal and canalicular membranes is still under debate.
Fruhwürth S, Kovacs WJ, Bittman R, Messner S, Röhrl C, Stangl H.   +5 more
europepmc   +8 more sources