Results 1 to 10 of about 56,597 (227)

Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice [PDF]

Journal of Translational Medicine, 2018
Background Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cholesterol enriched, and functional ...
Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu   +5 more
doaj   +6 more sources

Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease. [PDF]

PLoS ONE, 2018
BACKGROUND:We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA2 mass and activity, we hypothesized that ...
Ani Manichaikul, Xin-Qun Wang, Li Li, Jeanette Erdmann, Guillaume Lettre, Joshua C Bis, Dawn Waterworth, Mary Cushman, Nancy S Jenny, Wendy S Post, Walter Palmas, Michael Y Tsai, Lars Wallentin, Harvey White, Heribert Schunkert, Christopher J O'Donnell, David M Herrington, Stephen S Rich, Michelle L O'Donoghue, Annabelle Rodriguez   +19 more
doaj   +8 more sources

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. [PDF]

PLoS ONE, 2012
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein
Guodong Li, Ann M Thomas, Jessica A Williams, Bo Kong, Jie Liu, Yuka Inaba, Wen Xie, Grace L Guo   +7 more
doaj   +13 more sources

Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner. [PDF]

PLoS ONE
ObjectiveHomozygous knockout of scavenger receptor class B type I (SR-B1) in mice with atherogenic mutations (such as knockout of the apolipoprotein E or low density lipoprotein receptor genes) results in spontaneous or diet-induced coronary heart ...
Samuel K Lee, Ting Xiong, Alexander S Qian, Jeong-Ah Yoo, B Sumayyah H Sokeechand, Mark T Fuller, Peter L Gross, Richard C Austin, Suleiman A Igdoura, Bernardo L Trigatti   +9 more
doaj   +3 more sources

Novel Functions of Endothelial Scavenger Receptor Class B Type I. [PDF]

Curr Atheroscler Rep, 2021
Scavenger receptor class B type I (SR-BI) serves a key role in the reverse cholesterol transport in the liver as the high-affinity receptor for HDL. SR-BI is abundantly expressed in endothelium, and earlier works indicate that the receptor mediates anti-atherogenic actions of HDL. However, more recent studies uncovered novel functions of endothelial SR-
Yu L, Dai Y, Mineo C.
europepmc   +5 more sources

Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine [PDF]

Journal of Lipid Research, 2001
The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai, R. Jason Kirby, Philip N. Howles, David Y. Hui   +3 more
doaj   +2 more sources

Scavenger Receptor Class B, Type I, a CD36 Related Protein in Macrobrachium nipponense: Characterization, RNA Interference, and Expression Analysis with Different Dietary Lipid Sources [PDF]

International Journal of Genomics, 2016
The scavenger receptor class B, type I (SR-BI), is a member of the CD36 superfamily comprising transmembrane proteins involved in mammalian and fish lipid homeostasis regulation.
Zhili Ding, Na Luo, Youqin Kong, Jingfen Li, Yixiang Zhang, Fang Cao, Jinyun Ye   +6 more
doaj   +2 more sources

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism [PDF]

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +2 more sources

A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. [PDF]

J Virol, 2016
While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication in cells.
Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS.   +8 more
europepmc   +3 more sources

Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cytokines

Journal of Lipid Research, 2001
Multiple changes in HDL metabolism occur during infection and inflammation that could potentially impair the antiatherogenic functions of HDL. Scavenger receptor class B type I (SR-BI) promotes cholesterol efflux from peripheral cells and mediates ...
Weerapan Khovidhunkit, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, Kenneth R. Feingold   +4 more
doaj   +2 more sources