Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics [PDF]
Journal of Biological Chemistry, 2000 Both in vitro and in vivo studies of scavenger receptor class B type I (SR-BI) have implicated it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold increases) and low (2-fold increases) SR-BI expression in an inbred mouse ...
Yukihiko Ueda +5 more
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Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function. [PDF]
Oncoimmunology, 2016 Scavenger receptor class B type I (SR-B1) binds pathogen-associated molecular patterns participating in the regulation of the inflammatory reaction but there is no information regarding potential interactions between SR-B1 and the interferon system.
Vasquez M +13 more
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Correction: High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. [PDF]
PLoS One, 2015 PLOS ONE Staff.
europepmc +3 more sources
Frontiers in Physiology, 2023 High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller +15 more
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Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. [PDF]
Endocrinology, 2010 Kolmakova A +4 more
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Scavenger receptor class B type I: a multifunctional receptor [PDF]
Annals of the New York Academy of Sciences, 2011 The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear.
Alessandra Pecorelli +4 more
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. [PDF]
Breast Cancer Res, 2013 Danilo C +5 more
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Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions. [PDF]
Metabolism, 2014 Scavenger receptor class B type I (SR-BI), is a physiologically relevant HDL receptor that mediates selective uptake of lipoprotein (HDL)-derived cholesteryl ester (CE) in vitro and in vivo. Mammalian SR-BI is a 509-amino acid, ~82 kDa glycoprotein that contains N- and C-terminal cytoplasmic domains, two-transmembrane domains, as well as a large ...
Shen WJ +4 more
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Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver. [PDF]
Histochem Cell Biol, 2014 The high-density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediates selective cholesteryl ester uptake into the liver, which finally results in cholesterol secretion into the bile. Despite several reports, the distribution of hepatic SR-BI between the sinusoidal and canalicular membranes is still under debate.
Fruhwürth S +5 more
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Human scavenger receptor class B type I variants, lipid traits, and cardiovascular disease. [PDF]
Circ Cardiovasc Genet, 2014 Over the years, pioneering work from Monty Krieger’s laboratory has solidified the role of scavenger receptor class B type I (SR-BI) as a physiologically relevant lipoprotein receptor, especially in mouse models.1,2 It is safe to conclude that the complete absence of SR-BI in mice is associated with significant increases in circulating high-density ...
Vickers KC, Rodriguez A.
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