Results 101 to 110 of about 51,493 (310)

New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]

, 2013
Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien, Libert, Claude, Tuckermann, Jan, Vandevyver, Sofie   +3 more
core   +1 more source

Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function [PDF]

OncoImmunology, 2016
Scavenger receptor class B type I (SR-B1) binds pathogen-associated molecular patterns participating in the regulation of the inflammatory reaction but there is no information regarding potential interactions between SR-B1 and the interferon system.
Vasquez, Marcos, Fioravanti, Jessica, Aranda, Fernando, Paredes, Vladimir, Gomar, Celia, Ardaiz, Nuria, Fernandez-Ruiz, Veronica, Méndez, Miriam, Nistal-Villan, Estanislao, Larrea, Esther, Gao, Qinshan, Gonzalez-Aseguinolaza, Gloria, Prieto, Jesus, Berraondo, Pedro   +13 more
openaire   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV

Virology Journal, 2011
Background/Aim Hepatitis C virus (HCV) is a major threat as almost 3% of the world's population (350 million individual) and 10% of the Pakistani population is chronically infected with this virus. RNA interference (RNAi), a sequence-specific degradation
Ashfaq Usman Alli A, Ahmad Waqar, Khan Mahwish, Ijaz Bushra, Samreen Baila, Khaliq Saba, Jahan Shah, Hassan Sajida   +7 more
doaj   +1 more source

Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding

PLoS ONE, 2012
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein (HDL) into liver.
Li, G, Thomas, AM, Williams, JA, Kong, B, Liu, J, Inaba, Y, Xie, W, Guo, GL   +7 more
openaire   +4 more sources

Thermo‐Fluorescent Bactericidal Quantum Dots Based Smart Multifunctional Textiles via Molecular Surface Engineering and 3D‐Printed Interlocked Architectures

Advanced Healthcare Materials, EarlyView.
A versatile approach is presented for fabricating smart multifunctional textiles by integrating thermo‐fluorescent carbon dot/polymer nanocomposite coatings with 3D‐printed interlocked architectures. The fabrics exhibit temperature‐responsive fluorescence, durable hydrophobicity, strong antibacterial and antioxidant activity, and enhanced UV protection.
Poushali Das, Sayan Ganguly, Parham Khoshbakht Marvi, Misha Muthalali, Fatemeh Parniani, Shiza Hassan, Xiaowu (Shirley) Tang, Seshasai Srinivasan, Amin Reza Rajabzadeh   +8 more
wiley   +1 more source

The hepatic uptake of VLDL in lrp−ldlr−/−vldlr−/− mice is regulated by LPL activity and involves proteoglycans and SR-BI

Journal of Lipid Research, 2008
LPL activity plays an important role in preceding the VLDL remnant clearance via the three major apolipoprotein E (apoE)-recognizing receptors: the LDL receptor (LDLr), LDL receptor-related protein (LRP), and VLDL receptor (VLDLr).
Lihui Hu, Caroline C. van der Hoogt, Sonia M.S. Espirito Santo, Ruud Out, Kyriakos E. Kypreos, Bart J.M. van Vlijmen, Theo J.C. Van Berkel, Johannes A. Romijn, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen   +10 more
doaj   +1 more source

Potential immunosuppressive effects of Escherichia coli O157:H7 experimental infection on the bovine host [PDF]

, 2016
Background: Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7 are frequently detected in bovine faecal samples at slaughter. Cattle do not show clinical symptoms upon infection, but for humans the consequences after consuming contaminated ...
Cox, Eric, Kieckens, Evelien, Li, RW, Rybarczyk, Joanna, Vanrompay, Daisy   +4 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretions⃞

Journal of Lipid Research, 2007
LPL and endothelial lipase (EL) are associated with macrophages in human atherosclerotic lesions, and overexpression of LPL in mouse macrophages is associated with a greater extent of atherosclerosis.
Guosong Qiu, Alexander C. Ho, Willie Yu, John S. Hill   +3 more
doaj   +1 more source